Clock genes and energy metabolism

Hee Kyung Hong, Wenyu Huang, Kathryn Moynihan Ramsey, Biliana Marcheva, Joseph Bass*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Circadian timekeeping is a ubiquitous feature of all eukaryotes and allows appropriate temporal regulation of an organism's physiology, behavior, and metabolism to anticipate and respond to recurrent daily changes in the environment. Animal models provide strong evidence that disruption of circadian pathways are associated with metabolic dysregulation and sleep-related pathologies, while high-fat feeding reveals disrupted circadian rhythms of feeding, activity, and sleep. In humans, short sleep duration is associated with increased risk of metabolic syndrome, including obesity, diabetes, ­cardiovascular diseases, and cancer. Here, we examine emerging insight into how the circadian clock network influences energy metabolism.

Original languageEnglish (US)
Title of host publicationSleep Loss and Obesity
Subtitle of host publicationIntersecting Epidemics
PublisherSpringer New York
Pages13-32
Number of pages20
ISBN (Electronic)9781461434924
ISBN (Print)9781461434917
DOIs
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Medicine(all)

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