Clock genes and metabolic disease

Biliana Marcheva, Kathryn Moynihan Ramsey, Alison Affinati, Joseph Bass*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations


The circadian system is a key integrator of behavior and metabolism that synchronizes physiological processes with the rotation of the Earth on its axis. In mammals, the clock is present not only within the central pacemaker neurons of the hypothalamus, but also within extra-suprachiasmatic nucleus (SCN) regions of brain and nearly all peripheral tissues. Recent evidence suggests that the complex feedback networks that encompass both the circadian and metabolic systems are intimately intertwined and that disruption of either system leads to reciprocal disturbances in the other. We anticipate that improved understanding of the interconnections between the circadian and metabolic networks will open new windows on the treatment of sleep and metabolic disorders, including diabetes mellitus and obesity.

Original languageEnglish (US)
Pages (from-to)1638-1646
Number of pages9
JournalJournal of applied physiology
Issue number5
StatePublished - Nov 2009


  • Circadian rhythms
  • Diabetes mellitus
  • Metabolic syndrome
  • Sirtuins
  • Sleep disorders

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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