The analysis of means and variances in the proportion of activities of many small samples of normal chimeric tissue can lead to estimates of the extent of variegation of that tissue. The clone and patch size can be applied to developmental problems such as an estimation of the number of cells responsible for the formation of chemically induced tumors. The clone size of normal chimeric mouse epidermis was estimated to be 600 cells. The patch size was estimated to be 15,000 cells. Chemically induced skin tumors were estimated to have arisen from no more than 8 cells.
ASJC Scopus subject areas
- Statistics and Probability
- Modeling and Simulation
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Agricultural and Biological Sciences(all)
- Applied Mathematics