Clone and patch size in chimeric mouse skin

Philip M. Iannaccone

doi:10.1016/0025-5564(80)90093-0

Clone and patch size in chimeric mouse skin

Philip M. Iannaccone^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The analysis of means and variances in the proportion of activities of many small samples of normal chimeric tissue can lead to estimates of the extent of variegation of that tissue. The clone and patch size can be applied to developmental problems such as an estimation of the number of cells responsible for the formation of chemically induced tumors. The clone size of normal chimeric mouse epidermis was estimated to be 600 cells. The patch size was estimated to be 15,000 cells. Chemically induced skin tumors were estimated to have arisen from no more than 8 cells.

Original language	English (US)
Pages (from-to)	117-123
Number of pages	7
Journal	Mathematical Biosciences
Volume	51
Issue number	1-2
DOIs	https://doi.org/10.1016/0025-5564(80)90093-0
State	Published - 1980

ASJC Scopus subject areas

Statistics and Probability
Modeling and Simulation
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Agricultural and Biological Sciences
Applied Mathematics

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10.1016/0025-5564(80)90093-0

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title = "Clone and patch size in chimeric mouse skin",

abstract = "The analysis of means and variances in the proportion of activities of many small samples of normal chimeric tissue can lead to estimates of the extent of variegation of that tissue. The clone and patch size can be applied to developmental problems such as an estimation of the number of cells responsible for the formation of chemically induced tumors. The clone size of normal chimeric mouse epidermis was estimated to be 600 cells. The patch size was estimated to be 15,000 cells. Chemically induced skin tumors were estimated to have arisen from no more than 8 cells.",

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AU - Iannaccone, Philip M.

PY - 1980

Y1 - 1980

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AB - The analysis of means and variances in the proportion of activities of many small samples of normal chimeric tissue can lead to estimates of the extent of variegation of that tissue. The clone and patch size can be applied to developmental problems such as an estimation of the number of cells responsible for the formation of chemically induced tumors. The clone size of normal chimeric mouse epidermis was estimated to be 600 cells. The patch size was estimated to be 15,000 cells. Chemically induced skin tumors were estimated to have arisen from no more than 8 cells.

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Clone and patch size in chimeric mouse skin

Abstract

ASJC Scopus subject areas

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