Clone and patch size in chimeric mouse skin

Philip M. Iannaccone*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The analysis of means and variances in the proportion of activities of many small samples of normal chimeric tissue can lead to estimates of the extent of variegation of that tissue. The clone and patch size can be applied to developmental problems such as an estimation of the number of cells responsible for the formation of chemically induced tumors. The clone size of normal chimeric mouse epidermis was estimated to be 600 cells. The patch size was estimated to be 15,000 cells. Chemically induced skin tumors were estimated to have arisen from no more than 8 cells.

Original languageEnglish (US)
Pages (from-to)117-123
Number of pages7
JournalMathematical Biosciences
Issue number1-2
StatePublished - 1980

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics


Dive into the research topics of 'Clone and patch size in chimeric mouse skin'. Together they form a unique fingerprint.

Cite this