Cloning and characterization of human pancreatic adenocarcinoma genes

D. M. Mahvi; R. S. Metzgar; O. J. Finn

Cloning and characterization of human pancreatic adenocarcinoma genes

D. M. Mahvi, R. S. Metzgar, O. J. Finn

Surgery, Surgical Oncology Division

Research output: Contribution to journal › Article › peer-review

Abstract

Plasmids containing inserts representing pancreatic adenocarcinoma-specific genes have been isolated from a cDNA library. These genes are not amplified in the transformed genome and do not appear to be mutated. The level of transcription of one gene (2CF1) is increased in pancreatic adenocarcinoma, but not in the normal adult pancreas, or PBL. The protein product of this differentially expressed gene may be related to malignant transformation in pancreatic adenocarcinoma.

Original language	English (US)
Pages (from-to)	385-387
Number of pages	3
Journal	Surgical Forum
Volume	VOL. 36
State	Published - Jan 1 1985

ASJC Scopus subject areas

Surgery

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abstract = "Plasmids containing inserts representing pancreatic adenocarcinoma-specific genes have been isolated from a cDNA library. These genes are not amplified in the transformed genome and do not appear to be mutated. The level of transcription of one gene (2CF1) is increased in pancreatic adenocarcinoma, but not in the normal adult pancreas, or PBL. The protein product of this differentially expressed gene may be related to malignant transformation in pancreatic adenocarcinoma.",

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