TY - JOUR
T1 - Cloning and Expression of Canine Interleukin-10
AU - Lu, Ping
AU - Zucker, Keith
AU - Fuller, Laphalle
AU - Tzakis, Andreas
AU - Esquenazi, Violet
AU - Miller, Joshua
AU - Fuller, Laphalle
AU - Esquenazi, Violet
AU - Miller, Joshua
PY - 1995/12
Y1 - 1995/12
N2 - We describe here the cloning of canine IL-10 cDNA (GenBank accession No. U33843) and the expression of recombinant IL-10 in a dog kidney cell line (DK6247) and Chinese hamster ovary cells (CHO). Canine IL-10 exhibits strong sequence homology to the known sequences of human, mouse, rat, and bovine genes at nucleotide and amino acid levels. The IL-10 gene, when introduced into DK and CHO cell lines, produces recombinant IL-10 that causes an inhibitory effect on allogeneic MHC-driven lymphoproliferative responses.
AB - We describe here the cloning of canine IL-10 cDNA (GenBank accession No. U33843) and the expression of recombinant IL-10 in a dog kidney cell line (DK6247) and Chinese hamster ovary cells (CHO). Canine IL-10 exhibits strong sequence homology to the known sequences of human, mouse, rat, and bovine genes at nucleotide and amino acid levels. The IL-10 gene, when introduced into DK and CHO cell lines, produces recombinant IL-10 that causes an inhibitory effect on allogeneic MHC-driven lymphoproliferative responses.
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U2 - 10.1089/jir.1995.15.1103
DO - 10.1089/jir.1995.15.1103
M3 - Article
C2 - 8746793
AN - SCOPUS:0029561975
SN - 1079-9907
VL - 15
SP - 1103
EP - 1109
JO - Journal of Interferon and Cytokine Research
JF - Journal of Interferon and Cytokine Research
IS - 12
ER -