Cloning of the cDNA for Canine Interferon-γ

Keith Zucker*, Ping Lu, Violet Esquenazi, Joshua Miller

*Corresponding author for this work

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

We have taken advantage of conserved regions of cDNA sequences for interferon-γ (IFN-γ) from other species to design polymerase chain reaction (PCR) primers capable of amplifying the protein-coding region of the canine mRNA. We report here the cDNA cloning of this region from dog lymphocytes and the cDNA sequence. The predicted amino acid sequence is also reported and compared to the known sequences of these other species. The molecular clone for the canine IFN-γ will allow direct study of this important cytokine's role in graft rejection in the widely used experimental canine transplant model.

Original languageEnglish (US)
Pages (from-to)191-194
Number of pages4
JournalJournal of Interferon Research
Volume12
Issue number3
DOIs
StatePublished - Jun 1992

ASJC Scopus subject areas

  • Immunology
  • Virology

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