Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine transfer protein

David E. Cohen; Richard M. Green; Michele K. Wu; David R. Beier

doi:10.1016/S0167-4781(99)00163-3

Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine transfer protein

David E. Cohen^*, Richard M. Green, Michele K. Wu, David R. Beier

^*Corresponding author for this work

Medicine, Hepatology Division

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Phosphatidylcholine transfer protein (PC-TP) is a cytosolic protein that catalyzes intermembrane transfer of phosphatidylcholines in vitro. We have cloned a cDNA encoding the human ortholog of PC-TP and have determined its tissue-specific expression as well as genomic organization. Radiation hybrid mapping localized the human gene, PCTP, to chromosome 17q21-22 and PCR-based single strand conformation polymorphism analysis of an interspecific backcross assigned mouse Pctp to the region of syntenic conservation on chromosome 11. Copyright (C) 1999 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	265-270
Number of pages	6
Journal	Biochimica et Biophysica Acta - Gene Structure and Expression
Volume	1447
Issue number	2-3
DOIs	https://doi.org/10.1016/S0167-4781(99)00163-3
State	Published - Oct 28 1999

Keywords

Bile
Lipid
Liver
Phospholipid
Transfer Protein

ASJC Scopus subject areas

Genetics
Structural Biology
Biophysics
Biochemistry

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10.1016/S0167-4781(99)00163-3

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title = "Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine transfer protein",

abstract = "Phosphatidylcholine transfer protein (PC-TP) is a cytosolic protein that catalyzes intermembrane transfer of phosphatidylcholines in vitro. We have cloned a cDNA encoding the human ortholog of PC-TP and have determined its tissue-specific expression as well as genomic organization. Radiation hybrid mapping localized the human gene, PCTP, to chromosome 17q21-22 and PCR-based single strand conformation polymorphism analysis of an interspecific backcross assigned mouse Pctp to the region of syntenic conservation on chromosome 11. Copyright (C) 1999 Elsevier Science B.V.",

keywords = "Bile, Lipid, Liver, Phospholipid, Transfer Protein",

author = "Cohen, {David E.} and Green, {Richard M.} and Wu, {Michele K.} and Beier, {David R.}",

note = "Funding Information: This research was supported in part by a Pilot and Feasibility Grant (D.E. Cohen) from the Liver Research Center at Albert Einstein College of Medicine (DK41296, D.A. Shafritz, P.I.), NIH DK45639 (D.R. Beier) and the Program in Human Genetics at Albert Einstein College of Medicine. Support from the Alexandrine and Alexander L. Sinsheimer Fund (D.E. Cohen) is gratefully acknowledged. This work was performed while D.E. Cohen was a Pfizer Scholar in Cardiovascular Medicine and an American Liver Foundation Liver Scholar. The authors thank Ms. Holly Dushkin for expert technical assistance.",

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doi = "10.1016/S0167-4781(99)00163-3",

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TY - JOUR

T1 - Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine transfer protein

AU - Cohen, David E.

AU - Green, Richard M.

AU - Wu, Michele K.

AU - Beier, David R.

N1 - Funding Information: This research was supported in part by a Pilot and Feasibility Grant (D.E. Cohen) from the Liver Research Center at Albert Einstein College of Medicine (DK41296, D.A. Shafritz, P.I.), NIH DK45639 (D.R. Beier) and the Program in Human Genetics at Albert Einstein College of Medicine. Support from the Alexandrine and Alexander L. Sinsheimer Fund (D.E. Cohen) is gratefully acknowledged. This work was performed while D.E. Cohen was a Pfizer Scholar in Cardiovascular Medicine and an American Liver Foundation Liver Scholar. The authors thank Ms. Holly Dushkin for expert technical assistance.

PY - 1999/10/28

Y1 - 1999/10/28

N2 - Phosphatidylcholine transfer protein (PC-TP) is a cytosolic protein that catalyzes intermembrane transfer of phosphatidylcholines in vitro. We have cloned a cDNA encoding the human ortholog of PC-TP and have determined its tissue-specific expression as well as genomic organization. Radiation hybrid mapping localized the human gene, PCTP, to chromosome 17q21-22 and PCR-based single strand conformation polymorphism analysis of an interspecific backcross assigned mouse Pctp to the region of syntenic conservation on chromosome 11. Copyright (C) 1999 Elsevier Science B.V.

AB - Phosphatidylcholine transfer protein (PC-TP) is a cytosolic protein that catalyzes intermembrane transfer of phosphatidylcholines in vitro. We have cloned a cDNA encoding the human ortholog of PC-TP and have determined its tissue-specific expression as well as genomic organization. Radiation hybrid mapping localized the human gene, PCTP, to chromosome 17q21-22 and PCR-based single strand conformation polymorphism analysis of an interspecific backcross assigned mouse Pctp to the region of syntenic conservation on chromosome 11. Copyright (C) 1999 Elsevier Science B.V.

KW - Bile

KW - Lipid

KW - Liver

KW - Phospholipid

KW - Transfer Protein

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AN - SCOPUS:0032748021

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JO - Biochimica et Biophysica Acta - Gene Structure and Expression

JF - Biochimica et Biophysica Acta - Gene Structure and Expression

IS - 2-3

ER -

Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine transfer protein

Abstract

Keywords

ASJC Scopus subject areas

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