Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine transfer protein

David E. Cohen*, Richard M. Green, Michele K. Wu, David R. Beier

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Phosphatidylcholine transfer protein (PC-TP) is a cytosolic protein that catalyzes intermembrane transfer of phosphatidylcholines in vitro. We have cloned a cDNA encoding the human ortholog of PC-TP and have determined its tissue-specific expression as well as genomic organization. Radiation hybrid mapping localized the human gene, PCTP, to chromosome 17q21-22 and PCR-based single strand conformation polymorphism analysis of an interspecific backcross assigned mouse Pctp to the region of syntenic conservation on chromosome 11. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)265-270
Number of pages6
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1447
Issue number2-3
DOIs
StatePublished - Oct 28 1999

Keywords

  • Bile
  • Lipid
  • Liver
  • Phospholipid
  • Transfer Protein

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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