Closing the structure-to-function gap for LRRK2

Valerie Tokars, Chuyu Chen, Loukia Parisiadou*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations

Abstract

Variations in the LRRK2 gene represent one of the strongest genetic factors for Parkinson's disease (PD). It has become clear that structural knowledge of the encoded large multidomain LRRK2 protein will cast light on its biological function. The new study from Myasnikov, Zhu, et al. provides a high-resolution structure of the full-length LRRK2.

Original languageEnglish (US)
Pages (from-to)187-188
Number of pages2
JournalTrends in Biochemical Sciences
Volume47
Issue number3
DOIs
StatePublished - Mar 2022

Keywords

  • Parkinson's disease
  • cryo-EM
  • full-length leucine-rich repeat kinase 2 (LRRK2)
  • high-resolution structure

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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