Clozapine for treatment-refractory mania

Joseph R. Calabrese*, Susan E. Kimmel, Mark J. Woyshville, Daniel J. Rapport, Carl J. Faust, Paul A. Thompson, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Objective The efficacy of clozapine for treatment-resistant mania was examined in a prospective trial for patients with bipolar or schizoaffective disorder. Method The subjects were 25 acutely manic patients with either bipolar disorder (N=10) or schizoaffective disorder-bipolar subtype (N=15) for whom lithium, anticonvulsants, and neuroleptics had been ineffective, had produced intolerable side effects, or both. After a 7-day washout, the patients were treated with clozapine monotherapy. They were evaluated over 13 weeks with the Young Mania Rating Scale and the Brief Psychiatric Rating Scale (BPRS). Results Of the 25 patients, 18 (72%) exhibited marked improvement on the Young Mania Rating Scale, and eight (32%) exhibited marked improvement on the BPRS. The bipolar patients as compared to schizoaffective patients, and the nonrapid as compared to rapid cyclers, had significantly greater improvement in total BPRS score. Conclusions These results suggest that clozapine is an effective therapy for treatment-resistant bipolar and schizoaffective mania. (Am J Psychiatry 1996; 153:759-764).

Original languageEnglish (US)
Title of host publicationBipolar Disorder
Subtitle of host publicationThe Science of Mental Health
PublisherTaylor and Francis
Number of pages6
ISBN (Electronic)9781135712181
ISBN (Print)9780815337447
StatePublished - Jan 1 2019
Externally publishedYes

ASJC Scopus subject areas

  • Psychology(all)


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