CMV70-3P miRNA contributes to the CMV mediated glioma stemness and represents a target for glioma experimental therapy

Ilya V. Ulasov*, Natalya V. Kaverina, Dhimankrishna Ghosh, Marya A. Baryshnikova, Zaira G. Kadagidze, Apollon I. Karseladze, Anatoly Y. Baryshnikov, Charles S. Cobbs

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Glioblastoma multiforme (GBM) is a rapidly progressive brain tumor with a median survival of 15-19 months. Therapeutic resistance and recurrence of the disease is attributed to cancer stem cells (CSC). Here, we report that CMV70-3P miRNA encoded by CMV increases GBM CSC stemness. Inhibition of CMV70-3P expression using oligo inhibitors significantly attenuated the ability of primary glioma cells to proliferate and form neurospheres. At the molecular level, we show that CM70-3P increases expression of cellular SOX2. Collectively, these findings indicate that CMV70-3P is a potential regulator of CMV- mediated glioma progression and cancer stemness.

Original languageEnglish (US)
Pages (from-to)25989-25999
Number of pages11
JournalOncotarget
Volume8
Issue number16
DOIs
StatePublished - 2017

Keywords

  • Brain tumor
  • Cytomegalovirus
  • Glioma stem cells
  • MiRNA

ASJC Scopus subject areas

  • Oncology

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