CMV70-3P miRNA contributes to the CMV mediated glioma stemness and represents a target for glioma experimental therapy

Ilya V. Ulasov; Natalya V. Kaverina; Dhimankrishna Ghosh; Marya A. Baryshnikova; Zaira G. Kadagidze; Apollon I. Karseladze; Anatoly Y. Baryshnikov; Charles S. Cobbs

doi:10.18632/oncotarget.11175

CMV70-3P miRNA contributes to the CMV mediated glioma stemness and represents a target for glioma experimental therapy

Ilya V. Ulasov^*, Natalya V. Kaverina, Dhimankrishna Ghosh, Marya A. Baryshnikova, Zaira G. Kadagidze, Apollon I. Karseladze, Anatoly Y. Baryshnikov, Charles S. Cobbs

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Glioblastoma multiforme (GBM) is a rapidly progressive brain tumor with a median survival of 15-19 months. Therapeutic resistance and recurrence of the disease is attributed to cancer stem cells (CSC). Here, we report that CMV70-3P miRNA encoded by CMV increases GBM CSC stemness. Inhibition of CMV70-3P expression using oligo inhibitors significantly attenuated the ability of primary glioma cells to proliferate and form neurospheres. At the molecular level, we show that CM70-3P increases expression of cellular SOX2. Collectively, these findings indicate that CMV70-3P is a potential regulator of CMV- mediated glioma progression and cancer stemness.

Original language	English (US)
Pages (from-to)	25989-25999
Number of pages	11
Journal	Oncotarget
Volume	8
Issue number	16
DOIs	https://doi.org/10.18632/oncotarget.11175
State	Published - 2017

Funding

This work was funded by the NIH R01 R01 NS070289 (U.I.V, D.G and C.C.) and support from Russian Fund of Fundamental Research (# 11 411.0008700. 13.082 and No 13 411. 1008799.13.120 Russia, AB).

Keywords

Brain tumor
Cytomegalovirus
Glioma stem cells
MiRNA

ASJC Scopus subject areas

Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.18632/oncotarget.11175

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title = "CMV70-3P miRNA contributes to the CMV mediated glioma stemness and represents a target for glioma experimental therapy",

abstract = "Glioblastoma multiforme (GBM) is a rapidly progressive brain tumor with a median survival of 15-19 months. Therapeutic resistance and recurrence of the disease is attributed to cancer stem cells (CSC). Here, we report that CMV70-3P miRNA encoded by CMV increases GBM CSC stemness. Inhibition of CMV70-3P expression using oligo inhibitors significantly attenuated the ability of primary glioma cells to proliferate and form neurospheres. At the molecular level, we show that CM70-3P increases expression of cellular SOX2. Collectively, these findings indicate that CMV70-3P is a potential regulator of CMV- mediated glioma progression and cancer stemness.",

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author = "Ulasov, {Ilya V.} and Kaverina, {Natalya V.} and Dhimankrishna Ghosh and Baryshnikova, {Marya A.} and Kadagidze, {Zaira G.} and Karseladze, {Apollon I.} and Baryshnikov, {Anatoly Y.} and Cobbs, {Charles S.}",

note = "Funding Information: This work was funded by the NIH R01 R01 NS070289 (U.I.V, D.G and C.C.) and support from Russian Fund of Fundamental Research (# 11 411.0008700. 13.082 and No 13 411. 1008799.13.120 Russia, AB).",

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language = "English (US)",

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T1 - CMV70-3P miRNA contributes to the CMV mediated glioma stemness and represents a target for glioma experimental therapy

AU - Ulasov, Ilya V.

AU - Kaverina, Natalya V.

AU - Ghosh, Dhimankrishna

AU - Baryshnikova, Marya A.

AU - Kadagidze, Zaira G.

AU - Karseladze, Apollon I.

AU - Baryshnikov, Anatoly Y.

AU - Cobbs, Charles S.

N1 - Funding Information: This work was funded by the NIH R01 R01 NS070289 (U.I.V, D.G and C.C.) and support from Russian Fund of Fundamental Research (# 11 411.0008700. 13.082 and No 13 411. 1008799.13.120 Russia, AB).

PY - 2017

Y1 - 2017

N2 - Glioblastoma multiforme (GBM) is a rapidly progressive brain tumor with a median survival of 15-19 months. Therapeutic resistance and recurrence of the disease is attributed to cancer stem cells (CSC). Here, we report that CMV70-3P miRNA encoded by CMV increases GBM CSC stemness. Inhibition of CMV70-3P expression using oligo inhibitors significantly attenuated the ability of primary glioma cells to proliferate and form neurospheres. At the molecular level, we show that CM70-3P increases expression of cellular SOX2. Collectively, these findings indicate that CMV70-3P is a potential regulator of CMV- mediated glioma progression and cancer stemness.

AB - Glioblastoma multiforme (GBM) is a rapidly progressive brain tumor with a median survival of 15-19 months. Therapeutic resistance and recurrence of the disease is attributed to cancer stem cells (CSC). Here, we report that CMV70-3P miRNA encoded by CMV increases GBM CSC stemness. Inhibition of CMV70-3P expression using oligo inhibitors significantly attenuated the ability of primary glioma cells to proliferate and form neurospheres. At the molecular level, we show that CM70-3P increases expression of cellular SOX2. Collectively, these findings indicate that CMV70-3P is a potential regulator of CMV- mediated glioma progression and cancer stemness.

KW - Brain tumor

KW - Cytomegalovirus

KW - Glioma stem cells

KW - MiRNA

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CMV70-3P miRNA contributes to the CMV mediated glioma stemness and represents a target for glioma experimental therapy

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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