CNS involvement in the antisecretory action of [Met5]enkephalinamide on the rat intestine

David R. Brown*, Richard J. Miller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The effects of the stable enkephalin, [D-Ala2, Met5]enkephalinamide (DAMA) were examined on basal and stimulated fluid accumulation in intestinal loops of anesthetized Wistar-Furth rats. DAMA (0.1-3.0 μg, i.c.v.) dose-dependently increased basal fluid absorption in the medial ileum and decreased jejunal and proximal ileal fluid secretion after 4 h cholera toxin (1 μg/loop) pretreatment. The antisecretory effects of DAMA were blocked by naltrexone (1 mg/kg s.c.). Thus, the antisecretory effects of opioids may be partially mediated at CNS sites.

Original languageEnglish (US)
Pages (from-to)441-444
Number of pages4
JournalEuropean Journal of Pharmacology
Volume90
Issue number4
DOIs
StatePublished - Jun 17 1983

Keywords

  • Antidiarrheal activity
  • CNS site of action
  • Cholera toxin
  • Intestinal secretion
  • [D-Ala,Met]enkephalinamide

ASJC Scopus subject areas

  • Pharmacology

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