Coagulation factor VII gene haplotypes, obesity-related traits, and cardiovascular risk in young women

Alex P. Reiner, C. S. Carlson, M. J. Rieder, D. S. Siscovick, K. Liu, W. L. Chandler, D. Green, S. M. Schwartz, D. A. Nickerson

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Background: Associations between common F7 haplotypes, plasma factor VII (FVII) levels, and cardiovascular risk have recently been reported in population studies involving predominantly European men. Methods: We assessed associations between F7 haplotypes and cardiovascular risk in two US population-based studies: a case-control study of these alleles related to a decreased risk of arterial thrombotic outcomes such as myocardial infarction (MI) in young-to-middle-aged women (n = 671), and a cohort study of cardiovascular disease risk factors in young women (n = 1040). Results: The high-expression F7 haplotype B (containing the promoter variant allele -402A) was associated with an increased FVII level among controls, but not with MI risk. Women carrying a≥1 copy of the low FVII expression level haplotype C (containing the -401T/-323del/-122C and Gln353 alleles) had decreased FVII levels and decreased risk of MI (odds ratio 0.54, 95% CI 0.31-0.93) compared with women homozygous for the most common haplotype A. Haplotype C was also associated with a decreased body mass index (BMI) and an increased high-density lipoprotein (HDL) cholesterol level, but not with MI risk after adjustment for these metabolic risk factors. In a cohort study composed of young US women, individuals homozygous for haplotype C had a lower BMI and lower systolic blood pressure, but the association between the F7 haplotype and HDL cholesterol was not confirmed. Conclusion: Common FVII haplotypes may contribute to the risk of MI in women, but the mechanisms appear complex. The association between F7 haplotypes and MI susceptibility may be mediated in part through an influence on atherogenic risk factors such as BMI.

Original languageEnglish (US)
Pages (from-to)42-49
Number of pages8
JournalJournal of Thrombosis and Haemostasis
Volume5
Issue number1
DOIs
StatePublished - Jan 2007

Keywords

  • Factor VII
  • Haplotypes
  • Myocardial infarction
  • Obesity

ASJC Scopus subject areas

  • Hematology

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    Reiner, A. P., Carlson, C. S., Rieder, M. J., Siscovick, D. S., Liu, K., Chandler, W. L., Green, D., Schwartz, S. M., & Nickerson, D. A. (2007). Coagulation factor VII gene haplotypes, obesity-related traits, and cardiovascular risk in young women. Journal of Thrombosis and Haemostasis, 5(1), 42-49. https://doi.org/10.1111/j.1538-7836.2006.02279.x