Coagulation plasma factor levels are early indicators of graft nonfunction following liver transplantation in children

Ron Bilik, Riccardo A. Superina*, A. O. Poon

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Following liver transplantation, the decision to retransplant in cases in which graft function is marginal must be taken early. Plasma coagulation factor monitoring was evaluated as an early predictor of graft failure requiring retransplantation in the first posttransplant week. Plasma levels of fibrinogen, factors V, VII, VIII, IX, antithrombin III, protein C, and plasminogen were measured in all patients at 0, 12, 24, 48, 72, 96, and 120 hours posttransplant in 46 patients who received 56 grafts and results were compared between livers that failed early (group 1) and those that functioned adequately (group 2). Six grafts were included in group 1: one patient died before retransplantation, four were retransplanted once, and one patient was retransplanted twice. Three grafts had primary nonfunction (PNF), 2 had obstructed portal veins, and 1 had a long period of warm ischemia during the initial transplant. In group 1, plasma levels of factor V were significantly lower than in group 2 at 24, 48, and 72 hours posttransplant (21.2% ± 14.2%, 12.4% ± 4.5%, and 13.0% ± 5.0% v 39.1% ± 23.9%, 48.8% ± 31.9%, and 60.9% ± 25.9%; P < .05, P < .01, and P < .005, respectively). Similarly, plasma levels of factor VII were significantly lower in group 1 over the same period of time (7.3% ± 2.7%, 4.2% ± 1.8%, and 4.7% ± 2.5% v 27.4% ± 17.1%, 34.1% ± 21.6%, and 34.8% ± 18.6%, respectively; P < .005). Factor IX levels in group 1 grafts also were significantly lower than those in group 2, but only at 48 hours after transplantation (27.4% ± 12.5% v 54.1% ± 30.9%; P < .05). Regression analysis demonstrated a strong negative correlation between time after transplant and plasma levels of factors V, VII, and IX in group 1 grafts (r2 = .841, .90, and .81, respectively), in contrast with the positive correlation with time after transplant and plasma factor V and IX levels in group 2 grafts (r2 = .964 and .749, respectively). Plasma levels of fibrinogen, plasminogen, factor VIII, protein C, and antithrombin III were not helpful in predicting those grafts that required early retransplantation. We conclude that factor V, VII, and IX levels immediately after liver transplantation are the best predictors of ultimate graft function and may be the earliest indicators of the need for retransplantation.

Original languageEnglish (US)
Pages (from-to)302-306
Number of pages5
JournalJournal of Pediatric Surgery
Volume27
Issue number3
DOIs
StatePublished - Jan 1 1992

Fingerprint

Blood Coagulation Factors
Liver Transplantation
Transplants
Factor V
Factor VII
Factor IX
Antithrombin III
Plasminogen
Protein C
Fibrinogen
Antithrombin Proteins
Warm Ischemia
Factor VIII
Portal Vein

Keywords

  • Coagulation plasma factors
  • liver transplantation, children

ASJC Scopus subject areas

  • Surgery

Cite this

@article{db60d40a7fa44ea498fddaf6469f5e35,
title = "Coagulation plasma factor levels are early indicators of graft nonfunction following liver transplantation in children",
abstract = "Following liver transplantation, the decision to retransplant in cases in which graft function is marginal must be taken early. Plasma coagulation factor monitoring was evaluated as an early predictor of graft failure requiring retransplantation in the first posttransplant week. Plasma levels of fibrinogen, factors V, VII, VIII, IX, antithrombin III, protein C, and plasminogen were measured in all patients at 0, 12, 24, 48, 72, 96, and 120 hours posttransplant in 46 patients who received 56 grafts and results were compared between livers that failed early (group 1) and those that functioned adequately (group 2). Six grafts were included in group 1: one patient died before retransplantation, four were retransplanted once, and one patient was retransplanted twice. Three grafts had primary nonfunction (PNF), 2 had obstructed portal veins, and 1 had a long period of warm ischemia during the initial transplant. In group 1, plasma levels of factor V were significantly lower than in group 2 at 24, 48, and 72 hours posttransplant (21.2{\%} ± 14.2{\%}, 12.4{\%} ± 4.5{\%}, and 13.0{\%} ± 5.0{\%} v 39.1{\%} ± 23.9{\%}, 48.8{\%} ± 31.9{\%}, and 60.9{\%} ± 25.9{\%}; P < .05, P < .01, and P < .005, respectively). Similarly, plasma levels of factor VII were significantly lower in group 1 over the same period of time (7.3{\%} ± 2.7{\%}, 4.2{\%} ± 1.8{\%}, and 4.7{\%} ± 2.5{\%} v 27.4{\%} ± 17.1{\%}, 34.1{\%} ± 21.6{\%}, and 34.8{\%} ± 18.6{\%}, respectively; P < .005). Factor IX levels in group 1 grafts also were significantly lower than those in group 2, but only at 48 hours after transplantation (27.4{\%} ± 12.5{\%} v 54.1{\%} ± 30.9{\%}; P < .05). Regression analysis demonstrated a strong negative correlation between time after transplant and plasma levels of factors V, VII, and IX in group 1 grafts (r2 = .841, .90, and .81, respectively), in contrast with the positive correlation with time after transplant and plasma factor V and IX levels in group 2 grafts (r2 = .964 and .749, respectively). Plasma levels of fibrinogen, plasminogen, factor VIII, protein C, and antithrombin III were not helpful in predicting those grafts that required early retransplantation. We conclude that factor V, VII, and IX levels immediately after liver transplantation are the best predictors of ultimate graft function and may be the earliest indicators of the need for retransplantation.",
keywords = "Coagulation plasma factors, liver transplantation, children",
author = "Ron Bilik and Superina, {Riccardo A.} and Poon, {A. O.}",
year = "1992",
month = "1",
day = "1",
doi = "10.1016/0022-3468(92)90851-W",
language = "English (US)",
volume = "27",
pages = "302--306",
journal = "Journal of Pediatric Surgery",
issn = "0022-3468",
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}

Coagulation plasma factor levels are early indicators of graft nonfunction following liver transplantation in children. / Bilik, Ron; Superina, Riccardo A.; Poon, A. O.

In: Journal of Pediatric Surgery, Vol. 27, No. 3, 01.01.1992, p. 302-306.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Coagulation plasma factor levels are early indicators of graft nonfunction following liver transplantation in children

AU - Bilik, Ron

AU - Superina, Riccardo A.

AU - Poon, A. O.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Following liver transplantation, the decision to retransplant in cases in which graft function is marginal must be taken early. Plasma coagulation factor monitoring was evaluated as an early predictor of graft failure requiring retransplantation in the first posttransplant week. Plasma levels of fibrinogen, factors V, VII, VIII, IX, antithrombin III, protein C, and plasminogen were measured in all patients at 0, 12, 24, 48, 72, 96, and 120 hours posttransplant in 46 patients who received 56 grafts and results were compared between livers that failed early (group 1) and those that functioned adequately (group 2). Six grafts were included in group 1: one patient died before retransplantation, four were retransplanted once, and one patient was retransplanted twice. Three grafts had primary nonfunction (PNF), 2 had obstructed portal veins, and 1 had a long period of warm ischemia during the initial transplant. In group 1, plasma levels of factor V were significantly lower than in group 2 at 24, 48, and 72 hours posttransplant (21.2% ± 14.2%, 12.4% ± 4.5%, and 13.0% ± 5.0% v 39.1% ± 23.9%, 48.8% ± 31.9%, and 60.9% ± 25.9%; P < .05, P < .01, and P < .005, respectively). Similarly, plasma levels of factor VII were significantly lower in group 1 over the same period of time (7.3% ± 2.7%, 4.2% ± 1.8%, and 4.7% ± 2.5% v 27.4% ± 17.1%, 34.1% ± 21.6%, and 34.8% ± 18.6%, respectively; P < .005). Factor IX levels in group 1 grafts also were significantly lower than those in group 2, but only at 48 hours after transplantation (27.4% ± 12.5% v 54.1% ± 30.9%; P < .05). Regression analysis demonstrated a strong negative correlation between time after transplant and plasma levels of factors V, VII, and IX in group 1 grafts (r2 = .841, .90, and .81, respectively), in contrast with the positive correlation with time after transplant and plasma factor V and IX levels in group 2 grafts (r2 = .964 and .749, respectively). Plasma levels of fibrinogen, plasminogen, factor VIII, protein C, and antithrombin III were not helpful in predicting those grafts that required early retransplantation. We conclude that factor V, VII, and IX levels immediately after liver transplantation are the best predictors of ultimate graft function and may be the earliest indicators of the need for retransplantation.

AB - Following liver transplantation, the decision to retransplant in cases in which graft function is marginal must be taken early. Plasma coagulation factor monitoring was evaluated as an early predictor of graft failure requiring retransplantation in the first posttransplant week. Plasma levels of fibrinogen, factors V, VII, VIII, IX, antithrombin III, protein C, and plasminogen were measured in all patients at 0, 12, 24, 48, 72, 96, and 120 hours posttransplant in 46 patients who received 56 grafts and results were compared between livers that failed early (group 1) and those that functioned adequately (group 2). Six grafts were included in group 1: one patient died before retransplantation, four were retransplanted once, and one patient was retransplanted twice. Three grafts had primary nonfunction (PNF), 2 had obstructed portal veins, and 1 had a long period of warm ischemia during the initial transplant. In group 1, plasma levels of factor V were significantly lower than in group 2 at 24, 48, and 72 hours posttransplant (21.2% ± 14.2%, 12.4% ± 4.5%, and 13.0% ± 5.0% v 39.1% ± 23.9%, 48.8% ± 31.9%, and 60.9% ± 25.9%; P < .05, P < .01, and P < .005, respectively). Similarly, plasma levels of factor VII were significantly lower in group 1 over the same period of time (7.3% ± 2.7%, 4.2% ± 1.8%, and 4.7% ± 2.5% v 27.4% ± 17.1%, 34.1% ± 21.6%, and 34.8% ± 18.6%, respectively; P < .005). Factor IX levels in group 1 grafts also were significantly lower than those in group 2, but only at 48 hours after transplantation (27.4% ± 12.5% v 54.1% ± 30.9%; P < .05). Regression analysis demonstrated a strong negative correlation between time after transplant and plasma levels of factors V, VII, and IX in group 1 grafts (r2 = .841, .90, and .81, respectively), in contrast with the positive correlation with time after transplant and plasma factor V and IX levels in group 2 grafts (r2 = .964 and .749, respectively). Plasma levels of fibrinogen, plasminogen, factor VIII, protein C, and antithrombin III were not helpful in predicting those grafts that required early retransplantation. We conclude that factor V, VII, and IX levels immediately after liver transplantation are the best predictors of ultimate graft function and may be the earliest indicators of the need for retransplantation.

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