Coagulopathy of disseminated neuroblastoma

John Paul Scott*, Elaine Morgan

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

We performed coagulation studies in 16 patients with advanced neuroblastoma. Four of these patients had major hemorrhagic or thromboembolic complications. Abnormal coagulation screening tests were seen in all patients with active metastatic disease. We also measured plasma fibrinopeptide A, a sensitive measure of intravascular thrombin generation. Increased concentrations of fibrinopeptide A were found in each patient studied with active metastatic disease. Coagulopathy is a frequent finding in metastatic neuroblastoma and may cause severe morbidity. Laboratory studies suggesting either hyper- or hypocoagulability are frequent findings.

Original languageEnglish (US)
Pages (from-to)219-222
Number of pages4
JournalThe Journal of pediatrics
Volume103
Issue number2
DOIs
StatePublished - Aug 1983

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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