Cobalt-Schiff Base Complexes: Preclinical Research and Potential Therapeutic Uses

Elizabeth A. Bajema, Kaleigh F. Roberts, Thomas J. Meade*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Abstract

The use of metals in medicine has grown impressively in recent years as a result of greatly advanced understanding of biologically active metal complexes and metal-containing proteins. One landmark in this area was the introduction of cisplatin and related derivatives as anticancer drugs. As the body of literature continues to expand, it is necessary to inspect sub-classes of this group with more acute detail. This chapter will review preclinical research of cobalt complexes coordinated by Schiff base ligands. Cobalt-Schiff base complexes have a wide variety of potential therapeutic functions, including as antimicrobials, anticancer agents, and inhibitors of protein aggregation. While providing a broad introduction to this class of agents, this chapter will pay particular attention to agents for which mechanisms of actions have been studied. Appropriate methods to assess activity of these complexes will be reviewed, and promising preclinical complexes in each of the following therapeutic areas will be highlighted: antimicrobial, antiviral, cancer therapy, and Alzheimer's disease.

Original languageEnglish (US)
Title of host publicationMetal Ions in Life Sciences
PublisherDe Gruyter Open Ltd.
Pages267-301
Number of pages35
DOIs
StatePublished - 2019

Publication series

NameMetal Ions in Life Sciences
Volume19
ISSN (Print)1559-0836
ISSN (Electronic)2041-9821

ASJC Scopus subject areas

  • Medicine(all)

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