Cocaine-primed craving and its relationship to depressive symptomatology in individuals with cocaine dependence

Igor Elman*, Katherine H. Karlsgodt, David R. Gastfriend, Christopher F. Chabris, Hans C. Breiter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Several lines of evidence suggest a link between cocaine-primed craving and depressive symptomatology. The purpose of this study was to directly relate these two clinical phenomena. Thirty-three cocaine-dependent subjects were rated on the Hamilton Rating Scale for Depression (HRSD) at baseline and then administered an i.v. bolus of cocaine (0.2 mg/kg). Multiple regression analysis revealed that only the HRSD score was an independent predictor of cocaine-primed craving (F = 4.09; d.f. = 10,22; r = 0.81, p < 0.003) when baseline spontaneous craving during early withdrawal, age, gender, frequency of use, time since last use, monetary expenditure on cocaine and the Addiction Severity Index Drug Composite Scores were considered. These data support the hypothesis that depressive symptomatology affects cocaine-primed craving and that this relationship is relatively specific to symptoms defined by the HRSD and is not seen with a number of other clinical and demographic variables.

Original languageEnglish (US)
Pages (from-to)163-167
Number of pages5
JournalJournal of Psychopharmacology
Issue number2
StatePublished - 2002


  • Addiction Severity Index
  • Cocaine infusion
  • Euphoria
  • Hamilton Rating Scale for Depression
  • High
  • Multidimensional craving questionnaire
  • Non-treatment seekers

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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