Cocaine use and its effect on umbilical artery prostacyclin production

H. E. Cejtin*, M. T. Parsons, L. Wilson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Cocaine's association with adverse perinatal outcome has been attributed to its inhibition of norepinephrine uptake. This study examined the effect of cocaine on umbilical artery prostacyclin (PGI2) production. Umbilical arteries from pregnant cocaine users and controls were incubated in vitro and PGI2 levels in the media determined by measuring its stable metabolite, 6-keto-PGF, by RIA. Cocaine users showed a significant decrease (p<.05) in PGI2 production from their umbilical arteries when compared to controls. This appears to be through a direct effect of cocaine, as it decreases PGI2 production when added in vitro to umbilical arteries from controls. In addition, in vitro phospholipase A2 activity is inhibited by cocaine in a dose-dependent manner. These results suggest that the adverse perinatal outcome associated with cocaine use may be due in part to reduced vascular PGI2 production in the fetus.

Original languageEnglish (US)
Pages (from-to)249-257
Number of pages9
JournalProstaglandins
Volume40
Issue number3
DOIs
StatePublished - Sep 1990

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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