Abstract
The cochlear microphonic response was measured with differential electrodes from the first and third cochlear turns of normal guinea pigs and those treated with the ototoxic drug kanamycin. Histological controls showed that the outer hair cells in treated animals were missing over the basal half of the damaged cochleas, while the inner hair cells were intact. Measurements are consistent with the hypothesis that the potentials produced by inner hair cells are proportional to the velocity of the basilar membrane, whereas potentials generated by outer hair cells (which dominate the response of normal cochleas) are proportional to the displacement of the basilar membrane.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 356-358 |
| Number of pages | 3 |
| Journal | Science |
| Volume | 177 |
| Issue number | 4046 |
| DOIs | |
| State | Published - Jan 1 1972 |
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Cochlear inner and outer hair cells : Functional differences. / Dallos, Peter; Billone, M. C.; Durrant, J. D.; Wang, C. Y.; Raynor, S.
In: Science, Vol. 177, No. 4046, 01.01.1972, p. 356-358.Research output: Contribution to journal › Article
TY - JOUR
T1 - Cochlear inner and outer hair cells
T2 - Functional differences
AU - Dallos, Peter
AU - Billone, M. C.
AU - Durrant, J. D.
AU - Wang, C. Y.
AU - Raynor, S.
PY - 1972/1/1
Y1 - 1972/1/1
N2 - The cochlear microphonic response was measured with differential electrodes from the first and third cochlear turns of normal guinea pigs and those treated with the ototoxic drug kanamycin. Histological controls showed that the outer hair cells in treated animals were missing over the basal half of the damaged cochleas, while the inner hair cells were intact. Measurements are consistent with the hypothesis that the potentials produced by inner hair cells are proportional to the velocity of the basilar membrane, whereas potentials generated by outer hair cells (which dominate the response of normal cochleas) are proportional to the displacement of the basilar membrane.
AB - The cochlear microphonic response was measured with differential electrodes from the first and third cochlear turns of normal guinea pigs and those treated with the ototoxic drug kanamycin. Histological controls showed that the outer hair cells in treated animals were missing over the basal half of the damaged cochleas, while the inner hair cells were intact. Measurements are consistent with the hypothesis that the potentials produced by inner hair cells are proportional to the velocity of the basilar membrane, whereas potentials generated by outer hair cells (which dominate the response of normal cochleas) are proportional to the displacement of the basilar membrane.
UR - http://www.scopus.com/inward/record.url?scp=0015527224&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015527224&partnerID=8YFLogxK
U2 - 10.1126/science.177.4046.356
DO - 10.1126/science.177.4046.356
M3 - Article
VL - 177
SP - 356
EP - 358
JO - Science
JF - Science
SN - 0036-8075
IS - 4046
ER -