Cochlear inner and outer hair cells

Functional differences

Peter Dallos*, M. C. Billone, J. D. Durrant, C. Y. Wang, S. Raynor

*Corresponding author for this work

Research output: Contribution to journalArticle

174 Citations (Scopus)

Abstract

The cochlear microphonic response was measured with differential electrodes from the first and third cochlear turns of normal guinea pigs and those treated with the ototoxic drug kanamycin. Histological controls showed that the outer hair cells in treated animals were missing over the basal half of the damaged cochleas, while the inner hair cells were intact. Measurements are consistent with the hypothesis that the potentials produced by inner hair cells are proportional to the velocity of the basilar membrane, whereas potentials generated by outer hair cells (which dominate the response of normal cochleas) are proportional to the displacement of the basilar membrane.

Original languageEnglish (US)
Pages (from-to)356-358
Number of pages3
JournalScience
Volume177
Issue number4046
DOIs
StatePublished - Jan 1 1972

Fingerprint

Outer Auditory Hair Cells
Inner Auditory Hair Cells
Cochlea
Basilar Membrane
Kanamycin
Membrane Potentials
Electrodes
Guinea Pigs
Pharmaceutical Preparations

ASJC Scopus subject areas

  • General

Cite this

Dallos, P., Billone, M. C., Durrant, J. D., Wang, C. Y., & Raynor, S. (1972). Cochlear inner and outer hair cells: Functional differences. Science, 177(4046), 356-358. https://doi.org/10.1126/science.177.4046.356
Dallos, Peter ; Billone, M. C. ; Durrant, J. D. ; Wang, C. Y. ; Raynor, S. / Cochlear inner and outer hair cells : Functional differences. In: Science. 1972 ; Vol. 177, No. 4046. pp. 356-358.
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Dallos, P, Billone, MC, Durrant, JD, Wang, CY & Raynor, S 1972, 'Cochlear inner and outer hair cells: Functional differences', Science, vol. 177, no. 4046, pp. 356-358. https://doi.org/10.1126/science.177.4046.356

Cochlear inner and outer hair cells : Functional differences. / Dallos, Peter; Billone, M. C.; Durrant, J. D.; Wang, C. Y.; Raynor, S.

In: Science, Vol. 177, No. 4046, 01.01.1972, p. 356-358.

Research output: Contribution to journalArticle

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Dallos P, Billone MC, Durrant JD, Wang CY, Raynor S. Cochlear inner and outer hair cells: Functional differences. Science. 1972 Jan 1;177(4046):356-358. https://doi.org/10.1126/science.177.4046.356