TY - JOUR
T1 - Cochlear nucleus unit responses to pure tones in the unanesthetized rabbit
AU - Hui, Geoffrey S.
AU - Disterhoft, John F.
N1 - Funding Information:
Abbreviations: HRP-horseradish peroxidase, PSTH-poststimulus time histogram, CF-characteristic frequency, DCN-dorsal cochlear nucleus, AVCN-anteroventral central nucleus. ’ This research was supported by National Institutes of Health grant 5 ROl NS 12317. The technical assistance of Mrs. Helen Kwan is very much appreciated.
PY - 1980
Y1 - 1980
N2 - Seventy-six units were studied in the cochlear nucleus of unanesthetized, paralyzed rabbits. Most were located in the dorsal cochlear nucleus. Fifty-eight units were characterized according to their response area by the scheme of Evans and Nelson (1973, Exp. Brain Res., 17, 402–427): 22.5% showed purely excitatory response areas (type I/II), 72.5% showed mixed excitatory and inhibitory response areas (types III and IV), and 5% showed purely inhibitory response areas (type V). Ten units had virtually no spontaneous activity so were unclassifiable. When characterized according to the scheme of Pfeiffer (1966, Exp. Brain Res., 1, 220–235), 41% of the units were primary-like, 24% were choppers, 20% were pausers, 3% were buildup, and 1% were on units. There was no overall correlation between the two methods of unit classification, but type I/II units showed a high number of chopper patterns. Dorsal cochlear nucleus units in the unanesthetized rabbit showed response characteristics very similar to those which were reported in the decerebrate cat. However, there was a greater prevalence of primary-like, purely excitatory units in the rabbit dorsal cochlear nucleus. This may have reflected a species difference or have been due to technical considerations. It appears that the rabbit cochlear nucleus has very similar physiologic, as well as anatomic, characteristics as does that of the cat.
AB - Seventy-six units were studied in the cochlear nucleus of unanesthetized, paralyzed rabbits. Most were located in the dorsal cochlear nucleus. Fifty-eight units were characterized according to their response area by the scheme of Evans and Nelson (1973, Exp. Brain Res., 17, 402–427): 22.5% showed purely excitatory response areas (type I/II), 72.5% showed mixed excitatory and inhibitory response areas (types III and IV), and 5% showed purely inhibitory response areas (type V). Ten units had virtually no spontaneous activity so were unclassifiable. When characterized according to the scheme of Pfeiffer (1966, Exp. Brain Res., 1, 220–235), 41% of the units were primary-like, 24% were choppers, 20% were pausers, 3% were buildup, and 1% were on units. There was no overall correlation between the two methods of unit classification, but type I/II units showed a high number of chopper patterns. Dorsal cochlear nucleus units in the unanesthetized rabbit showed response characteristics very similar to those which were reported in the decerebrate cat. However, there was a greater prevalence of primary-like, purely excitatory units in the rabbit dorsal cochlear nucleus. This may have reflected a species difference or have been due to technical considerations. It appears that the rabbit cochlear nucleus has very similar physiologic, as well as anatomic, characteristics as does that of the cat.
KW - AVCN
KW - CF
KW - DCN
KW - HRP
KW - PSTH
KW - anteroventral central nucleus
KW - characteristic frequency
KW - dorsal cochlear nucleus
KW - horseradish peroxidase
KW - poststimulus time histogram
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U2 - 10.1016/0014-4886(80)90052-7
DO - 10.1016/0014-4886(80)90052-7
M3 - Article
C2 - 7409065
AN - SCOPUS:0018958999
VL - 69
SP - 576
EP - 588
JO - Neurodegeneration
JF - Neurodegeneration
SN - 0014-4886
IS - 3
ER -