TY - JOUR
T1 - Cochlear tuning estimates from level ratio functions of distortion product otoacoustic emissions
AU - Wilson, Uzma Shaheen
AU - Browning-Kamins, Jenna
AU - Durante, Alessandra Spada
AU - Boothalingam, Sriram
AU - Moleti, Arturo
AU - Sisto, Renata
AU - Dhar, Sumitrajit
N1 - Funding Information:
for this work was provided by the National Institute on Deafness and Other Communication Disorders Grant F32 DC017352 (awarded to U.S.W.), The Graduate School and Knowles Hearing Center at Northwestern University and the INAIL grant BRiC 2016 ID17/2016. Portions of this work were presented at the 44th Annual Scientific and Technology Conference of the American Auditory Society in Scottsdale, Arizona, the 41st Annual Mid-Winter Meeting of the Association for Research in Otolaryngology in San Diego, California, and the 2018 Hearing Across the Lifespan Conference in Lake Como, Italy.
Publisher Copyright:
© 2021 British Society of Audiology, International Society of Audiology, and Nordic Audiological Society.
PY - 2021
Y1 - 2021
N2 - Objective: Distortion product otoacoustic emission (DPOAE) levels plotted as a function of stimulus frequency ratio demonstrate a bandpass shape. This bandpass shape is narrower at higher frequencies compared to lower frequencies and thus has been thought to be related to cochlear mechanical tuning. Design: However, the frequency- and level-dependence of these functions above 8 kHz is largely unknown. Furthermore, how tuning estimates from these functions are related to behavioural tuning is not fully understood. Study Sample: From experiment 1, we report DPOAE level ratio functions (LRF) from seven normal-hearing, young-adults for f2 = 0.75–16 kHz and two stimulus levels of 62/52 and 52/37 dB FPL. We found that LRFs became narrower as a function of increasing frequency and decreasing level. Results: Tuning estimates from these functions increased as expected from 1-8 kHz. In experiment 2, we compared tuning estimates from DPOAE LRF to behavioural tuning in 24 normal-hearing, young adults for 1 and 4 kHz and found that behavioural tuning generally predicted DPOAE LRF estimated tuning. Conclusions: Our findings suggest that DPOAE LRFs generally reflect the tuning profile consistent with basilar membrane, neural, and behavioural tuning. However, further investigations are warranted to fully determine the use of DPOAE LRF as a clinical measure of cochlear tuning.
AB - Objective: Distortion product otoacoustic emission (DPOAE) levels plotted as a function of stimulus frequency ratio demonstrate a bandpass shape. This bandpass shape is narrower at higher frequencies compared to lower frequencies and thus has been thought to be related to cochlear mechanical tuning. Design: However, the frequency- and level-dependence of these functions above 8 kHz is largely unknown. Furthermore, how tuning estimates from these functions are related to behavioural tuning is not fully understood. Study Sample: From experiment 1, we report DPOAE level ratio functions (LRF) from seven normal-hearing, young-adults for f2 = 0.75–16 kHz and two stimulus levels of 62/52 and 52/37 dB FPL. We found that LRFs became narrower as a function of increasing frequency and decreasing level. Results: Tuning estimates from these functions increased as expected from 1-8 kHz. In experiment 2, we compared tuning estimates from DPOAE LRF to behavioural tuning in 24 normal-hearing, young adults for 1 and 4 kHz and found that behavioural tuning generally predicted DPOAE LRF estimated tuning. Conclusions: Our findings suggest that DPOAE LRFs generally reflect the tuning profile consistent with basilar membrane, neural, and behavioural tuning. However, further investigations are warranted to fully determine the use of DPOAE LRF as a clinical measure of cochlear tuning.
KW - Cochlear tuning
KW - behavioural tuning
KW - distortion product otoacoustic emissions
KW - level ratio function
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U2 - 10.1080/14992027.2021.1886352
DO - 10.1080/14992027.2021.1886352
M3 - Article
C2 - 33612052
AN - SCOPUS:85101276428
SN - 1499-2027
VL - 60
SP - 890
EP - 899
JO - International Journal of Audiology
JF - International Journal of Audiology
IS - 11
ER -