Cochlear tuning.. of mice and men

Shirin Farrahi, Roozbeh Ghaffari, Jonathan B. Sellon, Hideko H. Nakajima, Dennis M. Freeman*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

It has been suggested that humans discriminate different frequency sounds with greater selectivity than other mammals. However, mechanisms that could underlie higher frequency selectivity in humans are unclear. Recent studies show that the tectorial membrane (TM) supports longitudinally propagating waves, and the spread of excitation of these TM waves has been implicated in controlling the tuning properties in a mutant mouse model of hearing. Here we compare TM morphology and waves in humans and mice and show that despite some differences in morphology, the spread of excitation of TM waves is similar in spatial extent. However, the cochlear maps of humans and mice differ significantly, with similar cochlear distances mapping to a narrower range of best frequencies in humans than in mice. By coupling different frequency ranges, TM waves could contribute to differences in frequency tuning in mammals, with the smaller human range of frequencies corresponding to sharper frequency tuning.

Original languageEnglish (US)
Title of host publicationTo the Ear and Back Again - Advances in Auditory Biophysics
Subtitle of host publicationProceedings of the 13th Mechanics of Hearing Workshop
EditorsChristopher Bergevin, Sunil Puria
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735416703
DOIs
StatePublished - May 31 2018
Event13th Mechanics of Hearing Workshop: To the Ear and Back Again - Advances in Auditory Biophysics, MoH 2017 - St. Catharines, Canada
Duration: Jun 19 2017Jun 24 2017

Publication series

NameAIP Conference Proceedings
Volume1965
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other13th Mechanics of Hearing Workshop: To the Ear and Back Again - Advances in Auditory Biophysics, MoH 2017
CountryCanada
CitySt. Catharines
Period6/19/176/24/17

Fingerprint

mice
tuning
membranes
mammals
selectivity
acoustic frequencies
hearing
excitation
frequency ranges

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Farrahi, S., Ghaffari, R., Sellon, J. B., Nakajima, H. H., & Freeman, D. M. (2018). Cochlear tuning.. of mice and men. In C. Bergevin, & S. Puria (Eds.), To the Ear and Back Again - Advances in Auditory Biophysics: Proceedings of the 13th Mechanics of Hearing Workshop [040003] (AIP Conference Proceedings; Vol. 1965). American Institute of Physics Inc.. https://doi.org/10.1063/1.5038463
Farrahi, Shirin ; Ghaffari, Roozbeh ; Sellon, Jonathan B. ; Nakajima, Hideko H. ; Freeman, Dennis M. / Cochlear tuning.. of mice and men. To the Ear and Back Again - Advances in Auditory Biophysics: Proceedings of the 13th Mechanics of Hearing Workshop. editor / Christopher Bergevin ; Sunil Puria. American Institute of Physics Inc., 2018. (AIP Conference Proceedings).
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Farrahi, S, Ghaffari, R, Sellon, JB, Nakajima, HH & Freeman, DM 2018, Cochlear tuning.. of mice and men. in C Bergevin & S Puria (eds), To the Ear and Back Again - Advances in Auditory Biophysics: Proceedings of the 13th Mechanics of Hearing Workshop., 040003, AIP Conference Proceedings, vol. 1965, American Institute of Physics Inc., 13th Mechanics of Hearing Workshop: To the Ear and Back Again - Advances in Auditory Biophysics, MoH 2017, St. Catharines, Canada, 6/19/17. https://doi.org/10.1063/1.5038463

Cochlear tuning.. of mice and men. / Farrahi, Shirin; Ghaffari, Roozbeh; Sellon, Jonathan B.; Nakajima, Hideko H.; Freeman, Dennis M.

To the Ear and Back Again - Advances in Auditory Biophysics: Proceedings of the 13th Mechanics of Hearing Workshop. ed. / Christopher Bergevin; Sunil Puria. American Institute of Physics Inc., 2018. 040003 (AIP Conference Proceedings; Vol. 1965).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - It has been suggested that humans discriminate different frequency sounds with greater selectivity than other mammals. However, mechanisms that could underlie higher frequency selectivity in humans are unclear. Recent studies show that the tectorial membrane (TM) supports longitudinally propagating waves, and the spread of excitation of these TM waves has been implicated in controlling the tuning properties in a mutant mouse model of hearing. Here we compare TM morphology and waves in humans and mice and show that despite some differences in morphology, the spread of excitation of TM waves is similar in spatial extent. However, the cochlear maps of humans and mice differ significantly, with similar cochlear distances mapping to a narrower range of best frequencies in humans than in mice. By coupling different frequency ranges, TM waves could contribute to differences in frequency tuning in mammals, with the smaller human range of frequencies corresponding to sharper frequency tuning.

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Farrahi S, Ghaffari R, Sellon JB, Nakajima HH, Freeman DM. Cochlear tuning.. of mice and men. In Bergevin C, Puria S, editors, To the Ear and Back Again - Advances in Auditory Biophysics: Proceedings of the 13th Mechanics of Hearing Workshop. American Institute of Physics Inc. 2018. 040003. (AIP Conference Proceedings). https://doi.org/10.1063/1.5038463