Coencapsulation of arsenic-and platinum-based drugs for targeted cancer treatment

Haimei Chen*, Samuel Pazicni, Nancy L. Krett, Richard W. Ahn, James E. Penner-Hahn, Steven T. Rosen, Thomas V. O'Halloran

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

(Figure Presented) Two In one: A novel strategy for efficiently coencapsulating both arsenic- and platinum-based drugs into 100 nm-scale liposomes (NBs) relies on the formation of PtIIAsIII adducts. This co-loaded system presents a robust platform for further modification with targeting ligands and affords a method of improving the therapeutic efficacy of anticancer agents.

Original languageEnglish (US)
Pages (from-to)9295-9299
Number of pages5
JournalAngewandte Chemie - International Edition
Volume48
Issue number49
DOIs
StatePublished - Nov 23 2009

Keywords

  • Arsenic trioxide
  • Cisplatin
  • Coencapsulation
  • Liposome
  • Targeted delivery

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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