Coencapsulation of arsenic-and platinum-based drugs for targeted cancer treatment

Haimei Chen; Samuel Pazicni; Nancy L. Krett; Richard W. Ahn; James E. Penner-Hahn; Steven T. Rosen; Thomas V. O'Halloran

doi:10.1002/anie.200903655

Coencapsulation of arsenic-and platinum-based drugs for targeted cancer treatment

Haimei Chen^*, Samuel Pazicni, Nancy L. Krett, Richard W. Ahn, James E. Penner-Hahn, Steven T. Rosen, Thomas V. O'Halloran

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

(Figure Presented) Two In one: A novel strategy for efficiently coencapsulating both arsenic- and platinum-based drugs into 100 nm-scale liposomes (NBs) relies on the formation of Pt^IIAs^III adducts. This co-loaded system presents a robust platform for further modification with targeting ligands and affords a method of improving the therapeutic efficacy of anticancer agents.

Original language	English (US)
Pages (from-to)	9295-9299
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	49
DOIs	https://doi.org/10.1002/anie.200903655
State	Published - Nov 23 2009

Keywords

Arsenic trioxide
Cisplatin
Coencapsulation
Liposome
Targeted delivery

ASJC Scopus subject areas

General Chemistry
Catalysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.200903655

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title = "Coencapsulation of arsenic-and platinum-based drugs for targeted cancer treatment",

abstract = "(Figure Presented) Two In one: A novel strategy for efficiently coencapsulating both arsenic- and platinum-based drugs into 100 nm-scale liposomes (NBs) relies on the formation of PtIIAsIII adducts. This co-loaded system presents a robust platform for further modification with targeting ligands and affords a method of improving the therapeutic efficacy of anticancer agents.",

keywords = "Arsenic trioxide, Cisplatin, Coencapsulation, Liposome, Targeted delivery",

author = "Haimei Chen and Samuel Pazicni and Krett, {Nancy L.} and Ahn, {Richard W.} and Penner-Hahn, {James E.} and Rosen, {Steven T.} and O'Halloran, {Thomas V.}",

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T1 - Coencapsulation of arsenic-and platinum-based drugs for targeted cancer treatment

AU - Chen, Haimei

AU - Pazicni, Samuel

AU - Krett, Nancy L.

AU - Ahn, Richard W.

AU - Penner-Hahn, James E.

AU - Rosen, Steven T.

AU - O'Halloran, Thomas V.

PY - 2009/11/23

Y1 - 2009/11/23

N2 - (Figure Presented) Two In one: A novel strategy for efficiently coencapsulating both arsenic- and platinum-based drugs into 100 nm-scale liposomes (NBs) relies on the formation of PtIIAsIII adducts. This co-loaded system presents a robust platform for further modification with targeting ligands and affords a method of improving the therapeutic efficacy of anticancer agents.

AB - (Figure Presented) Two In one: A novel strategy for efficiently coencapsulating both arsenic- and platinum-based drugs into 100 nm-scale liposomes (NBs) relies on the formation of PtIIAsIII adducts. This co-loaded system presents a robust platform for further modification with targeting ligands and affords a method of improving the therapeutic efficacy of anticancer agents.

KW - Arsenic trioxide

KW - Cisplatin

KW - Coencapsulation

KW - Liposome

KW - Targeted delivery

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JF - Angewandte Chemie - International Edition

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Coencapsulation of arsenic-and platinum-based drugs for targeted cancer treatment

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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