Coexisting systemic lupus erythematosus and sickle cell disease: A diagnostic and therapeutic challenge

Nader A. Khalidi*, Harpinder Ajmani, John Varga

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Systemic lupus erythematosus (SLE) and sickle cell disease (SCD) are relatively common disorders with comparable prevalence among blacks. The coexistence of these 2 conditions in the same individual appears to be rare. We report 4 cases of coexisting SLE and SCD. These patients displayed a broad spectrum of musculoskeletal, central nervous system, and renal complications that may be associated with either SCD or SLE. Because of a substantial overlap between the clinical manifestations of these 2 disorders, the diagnosis of SLE in patients with SCD may be difficult to establish and is often delayed. Up to 23% of patients with SCD may have antinuclear antibodies. All patients in this series had antecedent SCD but new important complications from SLE.

Original languageEnglish (US)
Pages (from-to)86-92
Number of pages7
JournalJournal of Clinical Rheumatology
Volume11
Issue number2
DOIs
StatePublished - Apr 1 2005

Keywords

  • Multisystem involvement
  • Sickle cell disease
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology

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