Coffee intake, recurrence, and mortality in stage III colon cancer: Results from CALGB 89803 (Alliance)

Brendan J. Guercio, Kaori Sato, Donna Niedzwiecki, Xing Ye, Leonard B. Saltz, Robert J. Mayer, Rex B. Mowat, Renaud Whittom, Alexander Hantel, Al B Benson III, Daniel Atienza, Michael Messino, Hedy Kindler, Alan Venook, Frank B. Hu, Shuji Ogino, Kana Wu, Walter C. Willett, Edward L. Giovannucci, Jeffrey A. MeyerhardtCharles S. Fuchs*

*Corresponding author for this work

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Purpose: Observational studies have demonstrated increased colon cancer recurrence in states of relative hyperin-sulinemia, including sedentary lifestyle, obesity, and increased dietary glycemic load. Greater coffee consumption has been associated with decreased risk of type 2 diabetes and increased insulin sensitivity. The effect of coffee on colon cancer recurrence and survival is unknown. Patients and Methods: During and 6 months after adjuvant chemotherapy, 953 patients with stage III colon cancer prospectively reported dietary intake of caffeinated coffee, decaffeinated coffee, and nonherba tea, as well as 128 other items. We examined the influence of coffee, nonherbal tea, and caffeine on cancer recurrence and mortality using Cox proportional hazards regression. Results: Patients consuming 4 cups/d or more of total coffee experienced an adjusted hazard ratio (HR) for colon cancer recurrence or mortality of 0.58 (95% CI, 0.34 to 0.99), compared with never drinkers (Ptrend = .002). Patients consuming 4 cups/d or more of caffeinated coffee experienced significantly reduced cancer recurrence or mortality risk compared with abstainers (HR, 0.48; 95% CI, 0.25 to 0.91; Ptrend = .002), and increasing caffeine intake also conferred a significant reduction in cancer recurrence or mortality (HR, 0.66 across extreme quintiles; 95% CI, 0.47 to 0.93; Ptrend = .006). Nonherbal tea and decaffeinated coffee were not associated with patient outcome. The association of total coffee intake with improved outcomes seemed consistent across other predictors of cancer recurrence and mortality. Conclusion: Higher coffee intake may be associated with significantly reduced cancer recurrence and death in patients with stage III colon cancer.

Original languageEnglish (US)
Pages (from-to)3598-3607
Number of pages10
JournalJournal of Clinical Oncology
Volume33
Issue number31
DOIs
StatePublished - Nov 1 2015

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Coffee
Colonic Neoplasms
Recurrence
Mortality
Tea
Neoplasms
Caffeine
Sedentary Lifestyle
Adjuvant Chemotherapy
Type 2 Diabetes Mellitus
Observational Studies
Insulin Resistance
Obesity
Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Guercio, B. J., Sato, K., Niedzwiecki, D., Ye, X., Saltz, L. B., Mayer, R. J., ... Fuchs, C. S. (2015). Coffee intake, recurrence, and mortality in stage III colon cancer: Results from CALGB 89803 (Alliance). Journal of Clinical Oncology, 33(31), 3598-3607. https://doi.org/10.1200/JCO.2015.61.5062
Guercio, Brendan J. ; Sato, Kaori ; Niedzwiecki, Donna ; Ye, Xing ; Saltz, Leonard B. ; Mayer, Robert J. ; Mowat, Rex B. ; Whittom, Renaud ; Hantel, Alexander ; Benson III, Al B ; Atienza, Daniel ; Messino, Michael ; Kindler, Hedy ; Venook, Alan ; Hu, Frank B. ; Ogino, Shuji ; Wu, Kana ; Willett, Walter C. ; Giovannucci, Edward L. ; Meyerhardt, Jeffrey A. ; Fuchs, Charles S. / Coffee intake, recurrence, and mortality in stage III colon cancer : Results from CALGB 89803 (Alliance). In: Journal of Clinical Oncology. 2015 ; Vol. 33, No. 31. pp. 3598-3607.
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title = "Coffee intake, recurrence, and mortality in stage III colon cancer: Results from CALGB 89803 (Alliance)",
abstract = "Purpose: Observational studies have demonstrated increased colon cancer recurrence in states of relative hyperin-sulinemia, including sedentary lifestyle, obesity, and increased dietary glycemic load. Greater coffee consumption has been associated with decreased risk of type 2 diabetes and increased insulin sensitivity. The effect of coffee on colon cancer recurrence and survival is unknown. Patients and Methods: During and 6 months after adjuvant chemotherapy, 953 patients with stage III colon cancer prospectively reported dietary intake of caffeinated coffee, decaffeinated coffee, and nonherba tea, as well as 128 other items. We examined the influence of coffee, nonherbal tea, and caffeine on cancer recurrence and mortality using Cox proportional hazards regression. Results: Patients consuming 4 cups/d or more of total coffee experienced an adjusted hazard ratio (HR) for colon cancer recurrence or mortality of 0.58 (95{\%} CI, 0.34 to 0.99), compared with never drinkers (Ptrend = .002). Patients consuming 4 cups/d or more of caffeinated coffee experienced significantly reduced cancer recurrence or mortality risk compared with abstainers (HR, 0.48; 95{\%} CI, 0.25 to 0.91; Ptrend = .002), and increasing caffeine intake also conferred a significant reduction in cancer recurrence or mortality (HR, 0.66 across extreme quintiles; 95{\%} CI, 0.47 to 0.93; Ptrend = .006). Nonherbal tea and decaffeinated coffee were not associated with patient outcome. The association of total coffee intake with improved outcomes seemed consistent across other predictors of cancer recurrence and mortality. Conclusion: Higher coffee intake may be associated with significantly reduced cancer recurrence and death in patients with stage III colon cancer.",
author = "Guercio, {Brendan J.} and Kaori Sato and Donna Niedzwiecki and Xing Ye and Saltz, {Leonard B.} and Mayer, {Robert J.} and Mowat, {Rex B.} and Renaud Whittom and Alexander Hantel and {Benson III}, {Al B} and Daniel Atienza and Michael Messino and Hedy Kindler and Alan Venook and Hu, {Frank B.} and Shuji Ogino and Kana Wu and Willett, {Walter C.} and Giovannucci, {Edward L.} and Meyerhardt, {Jeffrey A.} and Fuchs, {Charles S.}",
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Guercio, BJ, Sato, K, Niedzwiecki, D, Ye, X, Saltz, LB, Mayer, RJ, Mowat, RB, Whittom, R, Hantel, A, Benson III, AB, Atienza, D, Messino, M, Kindler, H, Venook, A, Hu, FB, Ogino, S, Wu, K, Willett, WC, Giovannucci, EL, Meyerhardt, JA & Fuchs, CS 2015, 'Coffee intake, recurrence, and mortality in stage III colon cancer: Results from CALGB 89803 (Alliance)', Journal of Clinical Oncology, vol. 33, no. 31, pp. 3598-3607. https://doi.org/10.1200/JCO.2015.61.5062

Coffee intake, recurrence, and mortality in stage III colon cancer : Results from CALGB 89803 (Alliance). / Guercio, Brendan J.; Sato, Kaori; Niedzwiecki, Donna; Ye, Xing; Saltz, Leonard B.; Mayer, Robert J.; Mowat, Rex B.; Whittom, Renaud; Hantel, Alexander; Benson III, Al B; Atienza, Daniel; Messino, Michael; Kindler, Hedy; Venook, Alan; Hu, Frank B.; Ogino, Shuji; Wu, Kana; Willett, Walter C.; Giovannucci, Edward L.; Meyerhardt, Jeffrey A.; Fuchs, Charles S.

In: Journal of Clinical Oncology, Vol. 33, No. 31, 01.11.2015, p. 3598-3607.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Coffee intake, recurrence, and mortality in stage III colon cancer

T2 - Results from CALGB 89803 (Alliance)

AU - Guercio, Brendan J.

AU - Sato, Kaori

AU - Niedzwiecki, Donna

AU - Ye, Xing

AU - Saltz, Leonard B.

AU - Mayer, Robert J.

AU - Mowat, Rex B.

AU - Whittom, Renaud

AU - Hantel, Alexander

AU - Benson III, Al B

AU - Atienza, Daniel

AU - Messino, Michael

AU - Kindler, Hedy

AU - Venook, Alan

AU - Hu, Frank B.

AU - Ogino, Shuji

AU - Wu, Kana

AU - Willett, Walter C.

AU - Giovannucci, Edward L.

AU - Meyerhardt, Jeffrey A.

AU - Fuchs, Charles S.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Purpose: Observational studies have demonstrated increased colon cancer recurrence in states of relative hyperin-sulinemia, including sedentary lifestyle, obesity, and increased dietary glycemic load. Greater coffee consumption has been associated with decreased risk of type 2 diabetes and increased insulin sensitivity. The effect of coffee on colon cancer recurrence and survival is unknown. Patients and Methods: During and 6 months after adjuvant chemotherapy, 953 patients with stage III colon cancer prospectively reported dietary intake of caffeinated coffee, decaffeinated coffee, and nonherba tea, as well as 128 other items. We examined the influence of coffee, nonherbal tea, and caffeine on cancer recurrence and mortality using Cox proportional hazards regression. Results: Patients consuming 4 cups/d or more of total coffee experienced an adjusted hazard ratio (HR) for colon cancer recurrence or mortality of 0.58 (95% CI, 0.34 to 0.99), compared with never drinkers (Ptrend = .002). Patients consuming 4 cups/d or more of caffeinated coffee experienced significantly reduced cancer recurrence or mortality risk compared with abstainers (HR, 0.48; 95% CI, 0.25 to 0.91; Ptrend = .002), and increasing caffeine intake also conferred a significant reduction in cancer recurrence or mortality (HR, 0.66 across extreme quintiles; 95% CI, 0.47 to 0.93; Ptrend = .006). Nonherbal tea and decaffeinated coffee were not associated with patient outcome. The association of total coffee intake with improved outcomes seemed consistent across other predictors of cancer recurrence and mortality. Conclusion: Higher coffee intake may be associated with significantly reduced cancer recurrence and death in patients with stage III colon cancer.

AB - Purpose: Observational studies have demonstrated increased colon cancer recurrence in states of relative hyperin-sulinemia, including sedentary lifestyle, obesity, and increased dietary glycemic load. Greater coffee consumption has been associated with decreased risk of type 2 diabetes and increased insulin sensitivity. The effect of coffee on colon cancer recurrence and survival is unknown. Patients and Methods: During and 6 months after adjuvant chemotherapy, 953 patients with stage III colon cancer prospectively reported dietary intake of caffeinated coffee, decaffeinated coffee, and nonherba tea, as well as 128 other items. We examined the influence of coffee, nonherbal tea, and caffeine on cancer recurrence and mortality using Cox proportional hazards regression. Results: Patients consuming 4 cups/d or more of total coffee experienced an adjusted hazard ratio (HR) for colon cancer recurrence or mortality of 0.58 (95% CI, 0.34 to 0.99), compared with never drinkers (Ptrend = .002). Patients consuming 4 cups/d or more of caffeinated coffee experienced significantly reduced cancer recurrence or mortality risk compared with abstainers (HR, 0.48; 95% CI, 0.25 to 0.91; Ptrend = .002), and increasing caffeine intake also conferred a significant reduction in cancer recurrence or mortality (HR, 0.66 across extreme quintiles; 95% CI, 0.47 to 0.93; Ptrend = .006). Nonherbal tea and decaffeinated coffee were not associated with patient outcome. The association of total coffee intake with improved outcomes seemed consistent across other predictors of cancer recurrence and mortality. Conclusion: Higher coffee intake may be associated with significantly reduced cancer recurrence and death in patients with stage III colon cancer.

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