Cognitive and academic outcomes after pediatric liver transplantation: Functional outcomes group (FOG) results

Lisa G Sorensen, K. Neighbors, K. Martz, Frank A Zelko, J. C. Bucuvalas, Estella M Alonso

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

This multicenter study examined prevalence of cognitive and academic delays in children following liver transplant (LT). One hundred and forty-four patients ages 5-7 and 2 years post-LT were recruited through the SPLIT consortium and administered the Wechsler Preschool and Primary Scale of Intelligence, 3rd Edition (WPPSI-III), the Bracken Basic Concept Scale, Revised (BBCS-R), and the Wide Range Achievement Test, 4th edition (WRAT-4). Parents and teachers completed the Behavior Rating Inventory of Executive Function (BRIEF). Participants performed significantly below test norms on intelligence quotient (IQ) and achievement measures (Mean WPPSI-III Full Scale IQ = 94.7 ± 13.5; WRAT-4 Reading = 92.7 ± 17.2; WRAT-4 Math = 93.1 ± 15.4; p < 0001). Twenty-six percent of patients (14% expected) had 'mild to moderate' IQ delays (Full Scale IQ = 71-85) and 4% (2% expected) had 'serious' delays (Full Scale IQ = 70; p < 0.0001). Reading and/or math scores were weaker than IQ in 25%, suggesting learning disability, compared to 7% expected by CDC statistics (p < 0.0001). Executive deficits were noted on the BRIEF, especially by teacher report (Global Executive Composite = 58; p < 0.001). Results suggest a higher prevalence of cognitive and academic delays and learning problems in pediatric LT recipients compared to the normal population.

Original languageEnglish (US)
Pages (from-to)303-311
Number of pages9
JournalAmerican Journal of Transplantation
Volume11
Issue number2
DOIs
StatePublished - Feb 2011

Keywords

  • Cognition disorders
  • learning disorders
  • liver transplant
  • neuropsychological tests
  • pediatric liver disease
  • psychological aspects of organ transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Cognitive and academic outcomes after pediatric liver transplantation: Functional outcomes group (FOG) results'. Together they form a unique fingerprint.

Cite this