Cognitive Development One Year after Infantile Critical Pertussis

John T. Berger*, Michele E. Villalobos, Amy E. Clark, Richard Holubkov, Murray M. Pollack, Robert A. Berg, Joseph A. Carcillo, Heidi Dalton, Rick Harrison, Kathleen L. Meert, Christopher J.L. Newth, Thomas P. Shanley, David L. Wessel, Kanwaljeet J.S. Anand, Jerry J. Zimmerman, Ronald C. Sanders, Teresa Liu, Jeri S. Burr, Douglas F. Willson, Allan DoctorJ. Michael Dean, Tammara L. Jenkins, Carol E. Nicholson

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: Pertussis can cause life-threatening illness in infants. Data regarding neurodevelopment after pertussis remain scant. The aim of this study was to assess cognitive development of infants with critical pertussis 1 year after PICU discharge. Design: Prospective cohort study. Setting: Eight hospitals comprising the Eunice Kennedy Shriver National Institute for Child Health and Human Development Collaborative Pediatric Critical Care Research Network and 18 additional sites across the United States. Patients: Eligible patients had laboratory confirmation of pertussis infection, were less than 1 year old, and were admitted to the PICU for at least 24 hours. Interventions: The Mullen Scales of Early Learning was administered at a 1-year follow-up visit. Functional status was determined by examination and parental interview. Measurements and Main Results: Of 196 eligible patients, 111 (57%) completed the Mullen Scales of Early Learning. The mean scores for visual reception, receptive language, and expressive language domains were significantly lower than the norms (p < 0.001), but not fine and gross motor domains. Forty-one patients (37%) had abnormal scores in at least one domain and 10 (9%) had an Early Learning Composite score 2 or more sds below the population norms. Older age (p < 0.003) and Hispanic ethnicity (p < 0.008) were associated with lower mean Early Learning Composite score, but presenting symptoms and PICU course were not. Conclusions: Infants who survive critical pertussis often have neurodevelopmental deficits. These infants may benefit from routine neurodevelopmental screening.

Original languageEnglish (US)
Pages (from-to)89-97
Number of pages9
JournalPediatric Critical Care Medicine
Volume19
Issue number2
DOIs
StatePublished - Feb 1 2018

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Whooping Cough
Learning
Language
National Institute of Child Health and Human Development (U.S.)
Critical Care
Child Development
Hispanic Americans
Cohort Studies
Prospective Studies
Interviews
Pediatrics
Infection
Research
Population

Keywords

  • child development
  • intensive care
  • neurologic complications
  • outcome assessment
  • pertussis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Critical Care and Intensive Care Medicine

Cite this

Berger, J. T., Villalobos, M. E., Clark, A. E., Holubkov, R., Pollack, M. M., Berg, R. A., ... Nicholson, C. E. (2018). Cognitive Development One Year after Infantile Critical Pertussis. Pediatric Critical Care Medicine, 19(2), 89-97. https://doi.org/10.1097/PCC.0000000000001367
Berger, John T. ; Villalobos, Michele E. ; Clark, Amy E. ; Holubkov, Richard ; Pollack, Murray M. ; Berg, Robert A. ; Carcillo, Joseph A. ; Dalton, Heidi ; Harrison, Rick ; Meert, Kathleen L. ; Newth, Christopher J.L. ; Shanley, Thomas P. ; Wessel, David L. ; Anand, Kanwaljeet J.S. ; Zimmerman, Jerry J. ; Sanders, Ronald C. ; Liu, Teresa ; Burr, Jeri S. ; Willson, Douglas F. ; Doctor, Allan ; Dean, J. Michael ; Jenkins, Tammara L. ; Nicholson, Carol E. / Cognitive Development One Year after Infantile Critical Pertussis. In: Pediatric Critical Care Medicine. 2018 ; Vol. 19, No. 2. pp. 89-97.
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abstract = "Objectives: Pertussis can cause life-threatening illness in infants. Data regarding neurodevelopment after pertussis remain scant. The aim of this study was to assess cognitive development of infants with critical pertussis 1 year after PICU discharge. Design: Prospective cohort study. Setting: Eight hospitals comprising the Eunice Kennedy Shriver National Institute for Child Health and Human Development Collaborative Pediatric Critical Care Research Network and 18 additional sites across the United States. Patients: Eligible patients had laboratory confirmation of pertussis infection, were less than 1 year old, and were admitted to the PICU for at least 24 hours. Interventions: The Mullen Scales of Early Learning was administered at a 1-year follow-up visit. Functional status was determined by examination and parental interview. Measurements and Main Results: Of 196 eligible patients, 111 (57{\%}) completed the Mullen Scales of Early Learning. The mean scores for visual reception, receptive language, and expressive language domains were significantly lower than the norms (p < 0.001), but not fine and gross motor domains. Forty-one patients (37{\%}) had abnormal scores in at least one domain and 10 (9{\%}) had an Early Learning Composite score 2 or more sds below the population norms. Older age (p < 0.003) and Hispanic ethnicity (p < 0.008) were associated with lower mean Early Learning Composite score, but presenting symptoms and PICU course were not. Conclusions: Infants who survive critical pertussis often have neurodevelopmental deficits. These infants may benefit from routine neurodevelopmental screening.",
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Berger, JT, Villalobos, ME, Clark, AE, Holubkov, R, Pollack, MM, Berg, RA, Carcillo, JA, Dalton, H, Harrison, R, Meert, KL, Newth, CJL, Shanley, TP, Wessel, DL, Anand, KJS, Zimmerman, JJ, Sanders, RC, Liu, T, Burr, JS, Willson, DF, Doctor, A, Dean, JM, Jenkins, TL & Nicholson, CE 2018, 'Cognitive Development One Year after Infantile Critical Pertussis', Pediatric Critical Care Medicine, vol. 19, no. 2, pp. 89-97. https://doi.org/10.1097/PCC.0000000000001367

Cognitive Development One Year after Infantile Critical Pertussis. / Berger, John T.; Villalobos, Michele E.; Clark, Amy E.; Holubkov, Richard; Pollack, Murray M.; Berg, Robert A.; Carcillo, Joseph A.; Dalton, Heidi; Harrison, Rick; Meert, Kathleen L.; Newth, Christopher J.L.; Shanley, Thomas P.; Wessel, David L.; Anand, Kanwaljeet J.S.; Zimmerman, Jerry J.; Sanders, Ronald C.; Liu, Teresa; Burr, Jeri S.; Willson, Douglas F.; Doctor, Allan; Dean, J. Michael; Jenkins, Tammara L.; Nicholson, Carol E.

In: Pediatric Critical Care Medicine, Vol. 19, No. 2, 01.02.2018, p. 89-97.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cognitive Development One Year after Infantile Critical Pertussis

AU - Berger, John T.

AU - Villalobos, Michele E.

AU - Clark, Amy E.

AU - Holubkov, Richard

AU - Pollack, Murray M.

AU - Berg, Robert A.

AU - Carcillo, Joseph A.

AU - Dalton, Heidi

AU - Harrison, Rick

AU - Meert, Kathleen L.

AU - Newth, Christopher J.L.

AU - Shanley, Thomas P.

AU - Wessel, David L.

AU - Anand, Kanwaljeet J.S.

AU - Zimmerman, Jerry J.

AU - Sanders, Ronald C.

AU - Liu, Teresa

AU - Burr, Jeri S.

AU - Willson, Douglas F.

AU - Doctor, Allan

AU - Dean, J. Michael

AU - Jenkins, Tammara L.

AU - Nicholson, Carol E.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Objectives: Pertussis can cause life-threatening illness in infants. Data regarding neurodevelopment after pertussis remain scant. The aim of this study was to assess cognitive development of infants with critical pertussis 1 year after PICU discharge. Design: Prospective cohort study. Setting: Eight hospitals comprising the Eunice Kennedy Shriver National Institute for Child Health and Human Development Collaborative Pediatric Critical Care Research Network and 18 additional sites across the United States. Patients: Eligible patients had laboratory confirmation of pertussis infection, were less than 1 year old, and were admitted to the PICU for at least 24 hours. Interventions: The Mullen Scales of Early Learning was administered at a 1-year follow-up visit. Functional status was determined by examination and parental interview. Measurements and Main Results: Of 196 eligible patients, 111 (57%) completed the Mullen Scales of Early Learning. The mean scores for visual reception, receptive language, and expressive language domains were significantly lower than the norms (p < 0.001), but not fine and gross motor domains. Forty-one patients (37%) had abnormal scores in at least one domain and 10 (9%) had an Early Learning Composite score 2 or more sds below the population norms. Older age (p < 0.003) and Hispanic ethnicity (p < 0.008) were associated with lower mean Early Learning Composite score, but presenting symptoms and PICU course were not. Conclusions: Infants who survive critical pertussis often have neurodevelopmental deficits. These infants may benefit from routine neurodevelopmental screening.

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KW - child development

KW - intensive care

KW - neurologic complications

KW - outcome assessment

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Berger JT, Villalobos ME, Clark AE, Holubkov R, Pollack MM, Berg RA et al. Cognitive Development One Year after Infantile Critical Pertussis. Pediatric Critical Care Medicine. 2018 Feb 1;19(2):89-97. https://doi.org/10.1097/PCC.0000000000001367