Cognitive Development One Year after Infantile Critical Pertussis

John T. Berger*, Michele E. Villalobos, Amy E. Clark, Richard Holubkov, Murray M. Pollack, Robert A. Berg, Joseph A. Carcillo, Heidi Dalton, Rick Harrison, Kathleen L. Meert, Christopher J.L. Newth, Thomas P. Shanley, David L. Wessel, Kanwaljeet J.S. Anand, Jerry J. Zimmerman, Ronald C. Sanders, Teresa Liu, Jeri S. Burr, Douglas F. Willson, Allan DoctorJ. Michael Dean, Tammara L. Jenkins, Carol E. Nicholson

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Objectives: Pertussis can cause life-threatening illness in infants. Data regarding neurodevelopment after pertussis remain scant. The aim of this study was to assess cognitive development of infants with critical pertussis 1 year after PICU discharge. Design: Prospective cohort study. Setting: Eight hospitals comprising the Eunice Kennedy Shriver National Institute for Child Health and Human Development Collaborative Pediatric Critical Care Research Network and 18 additional sites across the United States. Patients: Eligible patients had laboratory confirmation of pertussis infection, were less than 1 year old, and were admitted to the PICU for at least 24 hours. Interventions: The Mullen Scales of Early Learning was administered at a 1-year follow-up visit. Functional status was determined by examination and parental interview. Measurements and Main Results: Of 196 eligible patients, 111 (57%) completed the Mullen Scales of Early Learning. The mean scores for visual reception, receptive language, and expressive language domains were significantly lower than the norms (p < 0.001), but not fine and gross motor domains. Forty-one patients (37%) had abnormal scores in at least one domain and 10 (9%) had an Early Learning Composite score 2 or more sds below the population norms. Older age (p < 0.003) and Hispanic ethnicity (p < 0.008) were associated with lower mean Early Learning Composite score, but presenting symptoms and PICU course were not. Conclusions: Infants who survive critical pertussis often have neurodevelopmental deficits. These infants may benefit from routine neurodevelopmental screening.

Original languageEnglish (US)
Pages (from-to)89-97
Number of pages9
JournalPediatric Critical Care Medicine
Volume19
Issue number2
DOIs
StatePublished - Feb 1 2018

Keywords

  • child development
  • intensive care
  • neurologic complications
  • outcome assessment
  • pertussis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Critical Care and Intensive Care Medicine

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    Berger, J. T., Villalobos, M. E., Clark, A. E., Holubkov, R., Pollack, M. M., Berg, R. A., Carcillo, J. A., Dalton, H., Harrison, R., Meert, K. L., Newth, C. J. L., Shanley, T. P., Wessel, D. L., Anand, K. J. S., Zimmerman, J. J., Sanders, R. C., Liu, T., Burr, J. S., Willson, D. F., ... Nicholson, C. E. (2018). Cognitive Development One Year after Infantile Critical Pertussis. Pediatric Critical Care Medicine, 19(2), 89-97. https://doi.org/10.1097/PCC.0000000000001367