Abstract
Objectives: Pertussis can cause life-threatening illness in infants. Data regarding neurodevelopment after pertussis remain scant. The aim of this study was to assess cognitive development of infants with critical pertussis 1 year after PICU discharge. Design: Prospective cohort study. Setting: Eight hospitals comprising the Eunice Kennedy Shriver National Institute for Child Health and Human Development Collaborative Pediatric Critical Care Research Network and 18 additional sites across the United States. Patients: Eligible patients had laboratory confirmation of pertussis infection, were less than 1 year old, and were admitted to the PICU for at least 24 hours. Interventions: The Mullen Scales of Early Learning was administered at a 1-year follow-up visit. Functional status was determined by examination and parental interview. Measurements and Main Results: Of 196 eligible patients, 111 (57%) completed the Mullen Scales of Early Learning. The mean scores for visual reception, receptive language, and expressive language domains were significantly lower than the norms (p < 0.001), but not fine and gross motor domains. Forty-one patients (37%) had abnormal scores in at least one domain and 10 (9%) had an Early Learning Composite score 2 or more sds below the population norms. Older age (p < 0.003) and Hispanic ethnicity (p < 0.008) were associated with lower mean Early Learning Composite score, but presenting symptoms and PICU course were not. Conclusions: Infants who survive critical pertussis often have neurodevelopmental deficits. These infants may benefit from routine neurodevelopmental screening.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 89-97 |
| Number of pages | 9 |
| Journal | Pediatric Critical Care Medicine |
| Volume | 19 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2018 |
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Keywords
- child development
- intensive care
- neurologic complications
- outcome assessment
- pertussis
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Critical Care and Intensive Care Medicine
Cite this
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Cognitive Development One Year after Infantile Critical Pertussis. / Berger, John T.; Villalobos, Michele E.; Clark, Amy E.; Holubkov, Richard; Pollack, Murray M.; Berg, Robert A.; Carcillo, Joseph A.; Dalton, Heidi; Harrison, Rick; Meert, Kathleen L.; Newth, Christopher J.L.; Shanley, Thomas P.; Wessel, David L.; Anand, Kanwaljeet J.S.; Zimmerman, Jerry J.; Sanders, Ronald C.; Liu, Teresa; Burr, Jeri S.; Willson, Douglas F.; Doctor, Allan; Dean, J. Michael; Jenkins, Tammara L.; Nicholson, Carol E.
In: Pediatric Critical Care Medicine, Vol. 19, No. 2, 01.02.2018, p. 89-97.Research output: Contribution to journal › Article
TY - JOUR
T1 - Cognitive Development One Year after Infantile Critical Pertussis
AU - Berger, John T.
AU - Villalobos, Michele E.
AU - Clark, Amy E.
AU - Holubkov, Richard
AU - Pollack, Murray M.
AU - Berg, Robert A.
AU - Carcillo, Joseph A.
AU - Dalton, Heidi
AU - Harrison, Rick
AU - Meert, Kathleen L.
AU - Newth, Christopher J.L.
AU - Shanley, Thomas P.
AU - Wessel, David L.
AU - Anand, Kanwaljeet J.S.
AU - Zimmerman, Jerry J.
AU - Sanders, Ronald C.
AU - Liu, Teresa
AU - Burr, Jeri S.
AU - Willson, Douglas F.
AU - Doctor, Allan
AU - Dean, J. Michael
AU - Jenkins, Tammara L.
AU - Nicholson, Carol E.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Objectives: Pertussis can cause life-threatening illness in infants. Data regarding neurodevelopment after pertussis remain scant. The aim of this study was to assess cognitive development of infants with critical pertussis 1 year after PICU discharge. Design: Prospective cohort study. Setting: Eight hospitals comprising the Eunice Kennedy Shriver National Institute for Child Health and Human Development Collaborative Pediatric Critical Care Research Network and 18 additional sites across the United States. Patients: Eligible patients had laboratory confirmation of pertussis infection, were less than 1 year old, and were admitted to the PICU for at least 24 hours. Interventions: The Mullen Scales of Early Learning was administered at a 1-year follow-up visit. Functional status was determined by examination and parental interview. Measurements and Main Results: Of 196 eligible patients, 111 (57%) completed the Mullen Scales of Early Learning. The mean scores for visual reception, receptive language, and expressive language domains were significantly lower than the norms (p < 0.001), but not fine and gross motor domains. Forty-one patients (37%) had abnormal scores in at least one domain and 10 (9%) had an Early Learning Composite score 2 or more sds below the population norms. Older age (p < 0.003) and Hispanic ethnicity (p < 0.008) were associated with lower mean Early Learning Composite score, but presenting symptoms and PICU course were not. Conclusions: Infants who survive critical pertussis often have neurodevelopmental deficits. These infants may benefit from routine neurodevelopmental screening.
AB - Objectives: Pertussis can cause life-threatening illness in infants. Data regarding neurodevelopment after pertussis remain scant. The aim of this study was to assess cognitive development of infants with critical pertussis 1 year after PICU discharge. Design: Prospective cohort study. Setting: Eight hospitals comprising the Eunice Kennedy Shriver National Institute for Child Health and Human Development Collaborative Pediatric Critical Care Research Network and 18 additional sites across the United States. Patients: Eligible patients had laboratory confirmation of pertussis infection, were less than 1 year old, and were admitted to the PICU for at least 24 hours. Interventions: The Mullen Scales of Early Learning was administered at a 1-year follow-up visit. Functional status was determined by examination and parental interview. Measurements and Main Results: Of 196 eligible patients, 111 (57%) completed the Mullen Scales of Early Learning. The mean scores for visual reception, receptive language, and expressive language domains were significantly lower than the norms (p < 0.001), but not fine and gross motor domains. Forty-one patients (37%) had abnormal scores in at least one domain and 10 (9%) had an Early Learning Composite score 2 or more sds below the population norms. Older age (p < 0.003) and Hispanic ethnicity (p < 0.008) were associated with lower mean Early Learning Composite score, but presenting symptoms and PICU course were not. Conclusions: Infants who survive critical pertussis often have neurodevelopmental deficits. These infants may benefit from routine neurodevelopmental screening.
KW - child development
KW - intensive care
KW - neurologic complications
KW - outcome assessment
KW - pertussis
UR - http://www.scopus.com/inward/record.url?scp=85048402596&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048402596&partnerID=8YFLogxK
U2 - 10.1097/PCC.0000000000001367
DO - 10.1097/PCC.0000000000001367
M3 - Article
C2 - 29117060
AN - SCOPUS:85048402596
VL - 19
SP - 89
EP - 97
JO - Pediatric Critical Care Medicine
JF - Pediatric Critical Care Medicine
SN - 1529-7535
IS - 2
ER -