Cognitive effects of 1- and 20-hertz repetitive transcranial magnetic stimulation in depression

Preliminary report

John T. Little*, Tim A. Kimbrell, Eric M. Wassermann, Jordan Grafman, Stacy Figueras, Robert T. Dunn, Aimee Danielson, Jennifer Repella, Teresa Huggins, Mark S. George, Robert M. Post

*Corresponding author for this work

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Objective: To determine the cognitive effects of daily repetitive transcranial magnetic stimulation (rTMS) administered under the conditions of a treatment trial for major depression. Background: Although daily left dorsal prefrontal rTMS has improved mood in some patients with treatment-refractory depression, potential cognitive side effects of extended daily treatment have not been systematically studied. Method: In a randomized double-blind treatment study, 10 subjects (mean age, 42 ± 15 years) with an episode of major depression received either 2 weeks of low-frequency (1 Hz) or high-frequency (20 Hz) rTMS (800 pulses, 20 trains over 20 minutes, 80% of motor threshold, 5 days per week) to the left dorsolateral prefrontal cortex and then were crossed over to the other treatment condition. Patients received cognitive testing at baseline and after the first and second weeks of low- or high-frequency rTMS, which was examined by repeated-measures ANOVA. Results: Of 16 cognitive measures tested after 1 or 2 weeks of rTMS compared with baseline status, none showed deterioration, and the only significant main treatment effect indicated improvement on a list-recall test from pre- to post-rTMS after 1 week (p < 0.05). Conclusions: These preliminary data suggest no gross deleterious cognitive effects of 2 weeks of 1- or 20-Hz rTMS at 80% of motor threshold over the left prefrontal cortex. Further cognitive studies of the effects of rTMS at other parameters used in clinical trials for mood disorders remain to be undertaken.

Original languageEnglish (US)
Pages (from-to)119-124
Number of pages6
JournalNeuropsychiatry, Neuropsychology and Behavioral Neurology
Volume13
Issue number2
StatePublished - Apr 1 2000

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Transcranial Magnetic Stimulation
Depression
Prefrontal Cortex
Therapeutics
Treatment-Resistant Depressive Disorder
Mood Disorders
Double-Blind Method
Analysis of Variance
Clinical Trials

ASJC Scopus subject areas

  • Psychology(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Little, John T. ; Kimbrell, Tim A. ; Wassermann, Eric M. ; Grafman, Jordan ; Figueras, Stacy ; Dunn, Robert T. ; Danielson, Aimee ; Repella, Jennifer ; Huggins, Teresa ; George, Mark S. ; Post, Robert M. / Cognitive effects of 1- and 20-hertz repetitive transcranial magnetic stimulation in depression : Preliminary report. In: Neuropsychiatry, Neuropsychology and Behavioral Neurology. 2000 ; Vol. 13, No. 2. pp. 119-124.
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Little, JT, Kimbrell, TA, Wassermann, EM, Grafman, J, Figueras, S, Dunn, RT, Danielson, A, Repella, J, Huggins, T, George, MS & Post, RM 2000, 'Cognitive effects of 1- and 20-hertz repetitive transcranial magnetic stimulation in depression: Preliminary report', Neuropsychiatry, Neuropsychology and Behavioral Neurology, vol. 13, no. 2, pp. 119-124.

Cognitive effects of 1- and 20-hertz repetitive transcranial magnetic stimulation in depression : Preliminary report. / Little, John T.; Kimbrell, Tim A.; Wassermann, Eric M.; Grafman, Jordan; Figueras, Stacy; Dunn, Robert T.; Danielson, Aimee; Repella, Jennifer; Huggins, Teresa; George, Mark S.; Post, Robert M.

In: Neuropsychiatry, Neuropsychology and Behavioral Neurology, Vol. 13, No. 2, 01.04.2000, p. 119-124.

Research output: Contribution to journalArticle

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T2 - Preliminary report

AU - Little, John T.

AU - Kimbrell, Tim A.

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AU - Grafman, Jordan

AU - Figueras, Stacy

AU - Dunn, Robert T.

AU - Danielson, Aimee

AU - Repella, Jennifer

AU - Huggins, Teresa

AU - George, Mark S.

AU - Post, Robert M.

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N2 - Objective: To determine the cognitive effects of daily repetitive transcranial magnetic stimulation (rTMS) administered under the conditions of a treatment trial for major depression. Background: Although daily left dorsal prefrontal rTMS has improved mood in some patients with treatment-refractory depression, potential cognitive side effects of extended daily treatment have not been systematically studied. Method: In a randomized double-blind treatment study, 10 subjects (mean age, 42 ± 15 years) with an episode of major depression received either 2 weeks of low-frequency (1 Hz) or high-frequency (20 Hz) rTMS (800 pulses, 20 trains over 20 minutes, 80% of motor threshold, 5 days per week) to the left dorsolateral prefrontal cortex and then were crossed over to the other treatment condition. Patients received cognitive testing at baseline and after the first and second weeks of low- or high-frequency rTMS, which was examined by repeated-measures ANOVA. Results: Of 16 cognitive measures tested after 1 or 2 weeks of rTMS compared with baseline status, none showed deterioration, and the only significant main treatment effect indicated improvement on a list-recall test from pre- to post-rTMS after 1 week (p < 0.05). Conclusions: These preliminary data suggest no gross deleterious cognitive effects of 2 weeks of 1- or 20-Hz rTMS at 80% of motor threshold over the left prefrontal cortex. Further cognitive studies of the effects of rTMS at other parameters used in clinical trials for mood disorders remain to be undertaken.

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