TY - JOUR
T1 - Cognitive Impairment and Dementia in Parkinson Disease
AU - Goldman, Jennifer G.
AU - Sieg, Erica
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/5
Y1 - 2020/5
N2 - In the comprehensive care of people with Parkinson disease (PD), recognition of cognitive impairment is essential. Cognitive impairment in PD can be varied in its clinical features and rates of progression and is now recognized to occur throughout the disease, from early, de novo to more advanced stages. However, the many factors related to the disease itself, underlying pathologies, comorbidities, and genetics may play a role in the development of mild cognitive impairment (PD-MCI) and dementia (PDD). To date, the field lacks curative or disease-modifying treatments for PD cognitive impairment and has few effective, robust symptomatic therapies for PDD or PD-MCI.
AB - In the comprehensive care of people with Parkinson disease (PD), recognition of cognitive impairment is essential. Cognitive impairment in PD can be varied in its clinical features and rates of progression and is now recognized to occur throughout the disease, from early, de novo to more advanced stages. However, the many factors related to the disease itself, underlying pathologies, comorbidities, and genetics may play a role in the development of mild cognitive impairment (PD-MCI) and dementia (PDD). To date, the field lacks curative or disease-modifying treatments for PD cognitive impairment and has few effective, robust symptomatic therapies for PDD or PD-MCI.
KW - Biomarker
KW - Dementia
KW - Diagnostic criteria
KW - Executive function
KW - Memory
KW - Mild cognitive impairment
KW - Neuropsychological assessment
UR - http://www.scopus.com/inward/record.url?scp=85082140835&partnerID=8YFLogxK
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U2 - 10.1016/j.cger.2020.01.001
DO - 10.1016/j.cger.2020.01.001
M3 - Review article
C2 - 32222308
AN - SCOPUS:85082140835
SN - 0749-0690
VL - 36
SP - 365
EP - 377
JO - Clinics in Geriatric Medicine
JF - Clinics in Geriatric Medicine
IS - 2
ER -