Cognitive impairment and psychiatric morbidity in HIV+ Zambians with new-onset Seizure

Lisa Kalungwana, Melissa A. Elafros, Omar K. Siddiqi, Christopher M. Bositis, Izukanji Sikazwe, Igor J. Koralnik, William H. Theodore, Gretchen L. Birbeck*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


A prospective cohort study of new-onset seizure in people with human immunodeficiency virus (HIV) in Zambia is ongoing to determine the incidence of subsequent epilepsy and risk factors for epileptogenesis in this population. At enrollment, we evaluated this cohort for cognitive impairment and psychiatric morbidity. Over 50% of participants had cognitive impairment and significant psychiatric morbidity. Most participants had advanced HIV disease based on CD4+ T-cell count and World Health Organization stage, but we found no association between cognitive impairment or psychiatric morbidity and HIV disease staging.

Original languageEnglish (US)
Pages (from-to)1254-1258
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number6
StatePublished - Dec 1 2014

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases


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