Cognitive impairment and psychiatric morbidity in HIV+ Zambians with new-onset Seizure

Lisa Kalungwana; Melissa A. Elafros; Omar K. Siddiqi; Christopher M. Bositis; Izukanji Sikazwe; Igor J. Koralnik; William H. Theodore; Gretchen L. Birbeck

doi:10.4269/ajtmh.13-0758

Cognitive impairment and psychiatric morbidity in HIV+ Zambians with new-onset Seizure

Lisa Kalungwana, Melissa A. Elafros, Omar K. Siddiqi, Christopher M. Bositis, Izukanji Sikazwe, Igor J. Koralnik, William H. Theodore, Gretchen L. Birbeck^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A prospective cohort study of new-onset seizure in people with human immunodeficiency virus (HIV) in Zambia is ongoing to determine the incidence of subsequent epilepsy and risk factors for epileptogenesis in this population. At enrollment, we evaluated this cohort for cognitive impairment and psychiatric morbidity. Over 50% of participants had cognitive impairment and significant psychiatric morbidity. Most participants had advanced HIV disease based on CD4+ T-cell count and World Health Organization stage, but we found no association between cognitive impairment or psychiatric morbidity and HIV disease staging.

Original language	English (US)
Pages (from-to)	1254-1258
Number of pages	5
Journal	American Journal of Tropical Medicine and Hygiene
Volume	91
Issue number	6
DOIs	https://doi.org/10.4269/ajtmh.13-0758
State	Published - Dec 1 2014

ASJC Scopus subject areas

Parasitology
Infectious Diseases
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4269/ajtmh.13-0758

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title = "Cognitive impairment and psychiatric morbidity in HIV+ Zambians with new-onset Seizure",

abstract = "A prospective cohort study of new-onset seizure in people with human immunodeficiency virus (HIV) in Zambia is ongoing to determine the incidence of subsequent epilepsy and risk factors for epileptogenesis in this population. At enrollment, we evaluated this cohort for cognitive impairment and psychiatric morbidity. Over 50% of participants had cognitive impairment and significant psychiatric morbidity. Most participants had advanced HIV disease based on CD4+ T-cell count and World Health Organization stage, but we found no association between cognitive impairment or psychiatric morbidity and HIV disease staging.",

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AU - Bositis, Christopher M.

AU - Sikazwe, Izukanji

AU - Koralnik, Igor J.

AU - Theodore, William H.

AU - Birbeck, Gretchen L.

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Cognitive impairment and psychiatric morbidity in HIV+ Zambians with new-onset Seizure

Abstract

ASJC Scopus subject areas

UN SDGs

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