Cognitive impairment in testicular cancer survivors 2 to 7 years after treatment

Ali Amidi*, Lisa M. Wu, Anders Degn Pedersen, Mimi Mehlsen, Christina Gundgaard Pedersen, Philip Rossen, Mads Agerbæk, Robert Zachariae

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Purpose: The aim of the present study was to determine the prevalence of cognitive impairment (CI) in a group of testicular (TC) survivors by comparing their neuropsychological test scores with normative data and to assess their performance in specific cognitive domains. Methods: Seventy-two TC survivors were evaluated 2 to 7 years post-treatment with a neuropsychological test battery that assessed multiple cognitive domains—attention and working memory, processing speed, verbal fluency, learning and memory, and executive functioning. Test scores were compared with normative data, and CI status was calculated for each participant. Results: In group-level analyses, survivors exhibited significantly impaired scores on a majority (9/12) of the neuropsychological outcomes (p < 0.01). In individual-level analyses, 62.5 % of the survivors were classified as having CI, significantly exceeding the expected normative frequency of 25 % (binomial test: p < 0.001). In particular, CI was observed in multiple outcomes related to verbal learning and memory (29 to 33 % of participants), visual learning and memory (14–28 %), processing speed (8–24 %), executive functioning (17 %), and attention and working memory (4–15 %). No association was found between treatment modality (surgery ± chemotherapy) and CI. Conclusions: The prevalence of CI in TC survivors was unexpectedly high, with survivors performing significantly worse than expected on a majority of the neuropsychological outcomes. While the findings are preliminary in nature, they still have important implications for the diagnosis and treatment of CI in TC survivors.

Original languageEnglish (US)
Pages (from-to)2973-2979
Number of pages7
JournalSupportive Care in Cancer
Volume23
Issue number10
DOIs
StatePublished - Oct 31 2015

Keywords

  • Cognition function
  • Cognitive impairment
  • Neuropsychological testing
  • Quality of life
  • Testicular cancer

ASJC Scopus subject areas

  • Oncology

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