TY - JOUR
T1 - Cognitive neuroscience of attention deficit hyperactivity disorder and hyperkinetic disorder
AU - Swanson, James
AU - Castellanos, F. Xavier
AU - Murias, Michael Andrew
AU - LaHoste, Gerald
AU - Kennedy, James
N1 - Funding Information:
The authors’w ork is supportedb y grantsf rom the Irvine Health Foundation and the National Institute of Mental Health (J Swansona nd M Murias) and from the Medical Research Council of Canada (J Kennedy).
PY - 1998/4
Y1 - 1998/4
N2 - Currently, diagnoses of attention deficit hyperactivity disorder (ADHD) and hyperkinetic disorder (HKD) are made on the basis of phenomenology, but information is accumulating from the neurosciences about the biological bases of these disorders. Recent studies addressing the neuropsychology, neuroanatomy, neurochemistry, and molecular biology of ADHD/HKD document abnormalities in well-defined neuroanatomical networks and neurochemical pathways. Magnetic resonance imaging (MRI) studies have shown that some regions of the frontal lobes (anterior superior and inferior) and basal ganglia (caudate nucleus and globus pallidus) are about 10% smaller in ADHD groups than in control groups of children, and molecular genetic studies have shown that diagnosis of ADHD is associated with polymorphisms in some dopamine genes (the dopamine D4 receptor gene and the dopamine transporter gene).
AB - Currently, diagnoses of attention deficit hyperactivity disorder (ADHD) and hyperkinetic disorder (HKD) are made on the basis of phenomenology, but information is accumulating from the neurosciences about the biological bases of these disorders. Recent studies addressing the neuropsychology, neuroanatomy, neurochemistry, and molecular biology of ADHD/HKD document abnormalities in well-defined neuroanatomical networks and neurochemical pathways. Magnetic resonance imaging (MRI) studies have shown that some regions of the frontal lobes (anterior superior and inferior) and basal ganglia (caudate nucleus and globus pallidus) are about 10% smaller in ADHD groups than in control groups of children, and molecular genetic studies have shown that diagnosis of ADHD is associated with polymorphisms in some dopamine genes (the dopamine D4 receptor gene and the dopamine transporter gene).
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U2 - 10.1016/S0959-4388(98)80150-5
DO - 10.1016/S0959-4388(98)80150-5
M3 - Article
C2 - 9635212
AN - SCOPUS:17344393861
SN - 0959-4388
VL - 8
SP - 263
EP - 271
JO - Current opinion in neurobiology
JF - Current opinion in neurobiology
IS - 2
ER -