Cognitive performance scores for the pediatric automated neuropsychological assessment metrics in childhood-onset systemic lupus erythematosus

Patricia Vega-Fernandez, Shana Vanderburgh White, Frank Zelko, Natasha M. Ruth, Deborah M. Levy, Eyal Muscal, Marisa S. Klein-Gitelman, Adam M. Huber, Lori B. Tucker, Tresa Roebuck-Spencer, Jun Ying, Hermine I. Brunner*

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Objective To develop and initially validate a global cognitive performance score (CPS) for the Pediatric Automated Neuropsychological Assessment Metrics (PedANAM) to serve as a screening tool of cognition in childhood lupus. Methods Patients (n = 166) completed the 9 subtests of the PedANAM battery, each of which provides 3 principal performance parameters (accuracy, mean reaction time for correct responses, and throughput). Cognitive ability was measured by formal neurocognitive testing or estimated by the Pediatric Perceived Cognitive Function Questionnaire-43 to determine the presence or absence of neurocognitive dysfunction (NCD). A subset of the data was used to develop 4 candidate PedANAM-CPS indices with supervised or unsupervised statistical approaches: PedANAM-CPSUWA, i.e., unweighted averages of the accuracy scores of all PedANAM subtests; PedANAM-CPSPCA, i.e., accuracy scores of all PedANAM subtests weighted through principal components analysis; PedANAM-CPSlogit, i.e., algorithm derived from logistic models to estimate NCD status based on the accuracy scores of all of the PedANAM subtests; and PedANAM-CPSmultiscore, i.e., algorithm derived from logistic models to estimate NCD status based on select PedANAM performance parameters. PedANAM-CPS candidates were validated using the remaining data. Results PedANAM-CPS indices were moderately correlated with each other (|r| > 0.65). All of the PedANAM-CPS indices discriminated children by NCD status across data sets (P < 0.036). The PedANAM-CPSmultiscore had the highest area under the receiver operating characteristic curve (AUC) across all data sets for identifying NCD status (AUC >0.74), followed by the PedANAM-CPSlogit, the PedANAM-CPSPCA, and the PedANAM-CPSUWA, respectively. Conclusion Based on preliminary validation and considering ease of use, the PedANAM-CPSmultiscore and the PedANAM-CPSPCA appear to be best suited as global measures of PedANAM performance.

Original languageEnglish (US)
Pages (from-to)1119-1127
Number of pages9
JournalArthritis Care and Research
Volume67
Issue number8
DOIs
StatePublished - Aug 1 2015

ASJC Scopus subject areas

  • Rheumatology

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    Vega-Fernandez, P., Vanderburgh White, S., Zelko, F., Ruth, N. M., Levy, D. M., Muscal, E., Klein-Gitelman, M. S., Huber, A. M., Tucker, L. B., Roebuck-Spencer, T., Ying, J., & Brunner, H. I. (2015). Cognitive performance scores for the pediatric automated neuropsychological assessment metrics in childhood-onset systemic lupus erythematosus. Arthritis Care and Research, 67(8), 1119-1127. https://doi.org/10.1002/acr.22571