Cognitive predictors of response to treatment for depression in multiple sclerosis

Laura J. Julian; David C. Mohr

doi:10.1176/jnp.2006.18.3.356

Cognitive predictors of response to treatment for depression in multiple sclerosis

Laura J. Julian, David C. Mohr

Preventive Medicine

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Cognitive impairment, particularly in the domain of executive functioning, has been demonstrated to predict poorer antidepressant medication treatment response. In this investigation, neuropsychological functioning was evaluated as a predictor of depression treatment response among 59 patients with multiple sclerosis. Performance on a Stroop task accounted for 28.7% of the variance in poorer pharmacologic antidepressant treatment response, as compared to less than 1% of the variance in two psychotherapy conditions. These results provide preliminary evidence to suggest that performance on neuropsychological measures may predict antidepressant treatment response in multiple sclerosis.

Original language	English (US)
Pages (from-to)	356-363
Number of pages	8
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	18
Issue number	3
DOIs	https://doi.org/10.1176/jnp.2006.18.3.356
State	Published - Jan 1 2006

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1176/jnp.2006.18.3.356

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Cognitive predictors of response to treatment for depression in multiple sclerosis

Abstract

ASJC Scopus subject areas

UN SDGs

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