Cognitive predictors of response to treatment for depression in multiple sclerosis

Laura J. Julian, David C. Mohr

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Cognitive impairment, particularly in the domain of executive functioning, has been demonstrated to predict poorer antidepressant medication treatment response. In this investigation, neuropsychological functioning was evaluated as a predictor of depression treatment response among 59 patients with multiple sclerosis. Performance on a Stroop task accounted for 28.7% of the variance in poorer pharmacologic antidepressant treatment response, as compared to less than 1% of the variance in two psychotherapy conditions. These results provide preliminary evidence to suggest that performance on neuropsychological measures may predict antidepressant treatment response in multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)356-363
Number of pages8
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number3
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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