Cognitive impairment, particularly in the domain of executive functioning, has been demonstrated to predict poorer antidepressant medication treatment response. In this investigation, neuropsychological functioning was evaluated as a predictor of depression treatment response among 59 patients with multiple sclerosis. Performance on a Stroop task accounted for 28.7% of the variance in poorer pharmacologic antidepressant treatment response, as compared to less than 1% of the variance in two psychotherapy conditions. These results provide preliminary evidence to suggest that performance on neuropsychological measures may predict antidepressant treatment response in multiple sclerosis.
|Original language||English (US)|
|Number of pages||8|
|Journal||Journal of Neuropsychiatry and Clinical Neurosciences|
|State||Published - Jan 1 2006|
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health