Cognitive proficiency in pediatric epilepsy

Lev Gottlieb, Frank A. Zelko*, Deok Soo Kim, Douglas R. Nordli

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Cognitive proficiency (CP) is a sensitive gauge of neurological status, but it is not typically viewed in relation to focal cerebral function. We examined CP and its relationship to general intellectual ability and seizure focus in 90 patients with pediatric epilepsy. CP was significantly lower than general ability (GA) in the overall sample. In particular, it was more deficient than GA in patients with right- than left-lateralized epilepsy onset, and in patients with frontal- than temporal-onset epilepsy. The discrepancy between CP and GA varied with participants' overall intelligence, being more pronounced (i.e., GA-CP difference larger) in individuals of lower overall ability. Deficits in CP are a defining characteristic of pediatric epilepsy and serve as an important marker of neurocognitive status, especially when seizures originate from a primary epileptogenic focus within the right hemisphere or the frontal lobe.

Original languageEnglish (US)
Pages (from-to)146-151
Number of pages6
JournalEpilepsy and Behavior
Issue number2
StatePublished - Feb 2012


  • Cognitive proficiency
  • Frontal
  • Intelligence
  • Lateralized
  • Pediatric epilepsy
  • Temporal

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience


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