TY - JOUR
T1 - Cold Erythema
T2 - A New Hypersensitivity Syndrome
AU - Shelley, Walter B.
AU - Caro, William A.
PY - 1962/5/26
Y1 - 1962/5/26
N2 - A 5-year-old boy reacted from infancy to cold stimuli with severe local pain, widespread erythema, and occasionally muscle spasm and collapse. In early life intractable constipation was also a feature. Physical examination and routine laboratory studies were normal as were specialized studies on serum and urine. The ice test produced pain and erythema without urticaria and was blocked by previous infiltration with procaine hydrochloride. Intradermal injections of histamine and bradykinin produced typical reactions; serotonin produced marked erythema without a wheal. Injected plasma from cold-incubated, autologous blood also resulted in marked erythema. Passive transfer tests were negative. Therapeutic trial with several classes of compounds offered only slight relief. It is felt that this cold sensitivity may be mediated by local serotonin release. Copyright, 1962, by American Medical Association
AB - A 5-year-old boy reacted from infancy to cold stimuli with severe local pain, widespread erythema, and occasionally muscle spasm and collapse. In early life intractable constipation was also a feature. Physical examination and routine laboratory studies were normal as were specialized studies on serum and urine. The ice test produced pain and erythema without urticaria and was blocked by previous infiltration with procaine hydrochloride. Intradermal injections of histamine and bradykinin produced typical reactions; serotonin produced marked erythema without a wheal. Injected plasma from cold-incubated, autologous blood also resulted in marked erythema. Passive transfer tests were negative. Therapeutic trial with several classes of compounds offered only slight relief. It is felt that this cold sensitivity may be mediated by local serotonin release. Copyright, 1962, by American Medical Association
UR - http://www.scopus.com/inward/record.url?scp=14544271327&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=14544271327&partnerID=8YFLogxK
U2 - 10.1001/jama.1962.03050210001001
DO - 10.1001/jama.1962.03050210001001
M3 - Article
C2 - 13911629
AN - SCOPUS:14544271327
SN - 0098-7484
VL - 180
SP - 639
EP - 642
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 8
ER -