Cold Erythema: A New Hypersensitivity Syndrome

Walter B. Shelley, William Allan Caro

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


A 5-year-old boy reacted from infancy to cold stimuli with severe local pain, widespread erythema, and occasionally muscle spasm and collapse. In early life intractable constipation was also a feature. Physical examination and routine laboratory studies were normal as were specialized studies on serum and urine. The ice test produced pain and erythema without urticaria and was blocked by previous infiltration with procaine hydrochloride. Intradermal injections of histamine and bradykinin produced typical reactions; serotonin produced marked erythema without a wheal. Injected plasma from cold-incubated, autologous blood also resulted in marked erythema. Passive transfer tests were negative. Therapeutic trial with several classes of compounds offered only slight relief. It is felt that this cold sensitivity may be mediated by local serotonin release. Copyright, 1962, by American Medical Association

Original languageEnglish (US)
Pages (from-to)639-642
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Issue number8
StatePublished - May 26 1962

ASJC Scopus subject areas

  • Medicine(all)


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