Collagen-I and fibronectin modified three-dimensional electrospun PLGA scaffolds for long-term in vitro maintenance of functional hepatocytes

Keyphrases

• Three-dimensional (3D) 100%
• Collagen I 100%
• Poly(lactic-co-glycolic acid) 100%
• Fibronectin 100%
• In Vitro Maintenance 100%
• Electrospun 100%
• Functional Hepatocytes 100%
• Extracellular Matrix Protein 1 (ECM1) 57%
• Gene Expression 42%
• Collagen 42%
• Functional Properties 42%
• Synergistic Effect 28%
• 3D Scaffold 28%
• I to 28%
• Liver Cells 28%
• Protein-modified 28%
• CYP3A7 28%
• Culture Group 28%
• Cell Behavior 14%
• Hepatocytes 14%
• Liver-specific 14%
• Specific Genes 14%
• Primary Hepatocytes 14%
• Cytochrome P450 3A4 (CYP3A4) 14%
• Single Cell Protein 14%
• Multi-protein 14%
• Native Ecosystems 14%
• Cultured Cells 14%
• 4-fold 14%
• Drug Screening 14%
• In Vitro Culture 14%
• Highly Porous 14%
• Cytochrome P450 Enzymes 14%
• Albumin 14%
• Total Protein Content 14%
• Liver Extracellular Matrix 14%
• Chemisorption 14%
• Culture Time 14%
• Albumin Gene 14%
• Optimum Ratio 14%
• Electrospun Scaffolds 14%
• CYP3A4 Gene 14%
• Albumin Secretion 14%
• Huh7.5 14%
• Viability Property 14%
• Cell Seeding Efficiency 14%

Biochemistry, Genetics and Molecular Biology

• Hepatocyte 100%
• Fibronectin 100%
• Gene Expression 42%
• Extracellular Matrix Proteins 42%
• Scleroprotein 42%
• Albumin 42%
• CYP3A4 28%
• CYP3A7 28%
• Cell Function 14%
• Protein Content 14%
• Drug Screening 14%
• Extracellular Matrix Protein 14%
• Porosity 14%
• Cytochrome P450 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Polyglactin 100%
• Fibronectin 100%
• Scleroprotein 42%
• Albumin 42%
• CYP3A4 28%
• CYP3A7 28%
• Drug Screening 14%
• Cytochrome P450 14%
• Matrix Protein 14%