| Original language | English (US) |
|---|---|
| Pages (from-to) | 439-446 |
| Number of pages | 8 |
| Journal | Human pathology |
| Volume | 16 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1985 |
ASJC Scopus subject areas
- Pathology and Forensic Medicine
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Collagen types in fibrosarcoma : Absence of type III collagen in reticulin. / Hall, Jackson; Tseng, Scheffer C.G.; Timpl, Rubert et al.
In: Human pathology, Vol. 16, No. 5, 05.1985, p. 439-446.Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Collagen types in fibrosarcoma
T2 - Absence of type III collagen in reticulin
AU - Hall, Jackson
AU - Tseng, Scheffer C.G.
AU - Timpl, Rubert
AU - Hendrix, Mary J.C.
AU - Stern, Robert
N1 - Funding Information: The di,"tgnosis of human soft tissue sarcomas often presents problems for snrgical pathologists. These heterogeneous lesions are usually diagnosed on the basis of cell pattern recognition. The histogenesis, cell of origin, or basic biology of these tumors is often unknown. The stroma of these sarcomas supports growth, endows the tumor with unique properties, and is a manifestation of phenotypic expresslon. Collagen, the major structnral protein component of tumor stroma, is now recognized as a family of proteins, each a different gene product. 1 Analysis of the tnatrix collagens may potentially provide sotne insight into the biology of these poorly tmderstood tumors. We examined a fibrosarcotna, presumably the most straightforward of these tumors. However, even this tumor can be characterized by a wide variety of manifestations and may be a diagnostic problem. In the present case, equivocal diagnoses were made fi'om the initial excisional biopsies. Diagnoses rendered included a fibrous variant of a malignant fibrous histocytoma, undifferentiated rhabdomyosarcoma, fibrosarcoma, and undifferentiated liposarcoma. The tumor tissue used for the extraction of collagens was obtained from the amputation specimen. We present a biochemical analysis of the types of collagens found in tiffs tumor, as well as the result of immunofluorescence microscopy with type-specific collagen antibodies. Types I and V collagen were present, but no trace of type III collagen could be found in the tumor stroma. All type III collagen was restricted to the walls of blood vessels. Tltis ttunor stained with a reticulin stain. Reticulin may be a pro-teoglyean or some other carbohydrate moiety associated with an immature pe.ricellular form of type I collagen and, as shown in this case, need not be associated with type III collagen. The latter is often incorrectly referred to by histopathologists as reticular collagen. This case is an example of th~ derivation of int-portant information concerning the biology of rite extracellular matrix and the type-specitic collagens cisco, School of Medicine, San Francisco, California, the iMax-Planck-lnstitut fur Biochemie, Martinsreid bet Munchen, Federal Republic of Germany, and *Department of Anatomy, University of Arizona, School of Medicine, Tuscon, Arizona. Accepted for publication September 25, 198-t. Supported by grant CA 25179 awarded by the National Cancer Institute, NIH, DIIIIS, to Dr.
PY - 1985/5
Y1 - 1985/5
UR - http://www.scopus.com/inward/record.url?scp=0022254726&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022254726&partnerID=8YFLogxK
U2 - 10.1016/S0046-8177(85)80080-0
DO - 10.1016/S0046-8177(85)80080-0
M3 - Article
C2 - 3886521
AN - SCOPUS:0022254726
SN - 0046-8177
VL - 16
SP - 439
EP - 446
JO - Human Pathology
JF - Human Pathology
IS - 5
ER -