Collecting back-reflected photons in photoacoustic microscopy

Hao F. Zhang, Jing Wang, Qing Wei, Tan Liu, Shuliang Jiao, Carmen A. Puliafito

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Since the photoacoustic effect relies only on the absorbed optical energy, the back-reflected photons from samples in optical-resolution photoacoustic microscopy are usually discarded. By employing a 2 × 2 single-mode fiber optical coupler in a laser-scanning optical-resolution photoacoustic microscope for delivering the illuminating laser light and collecting the back reflected photons, a fiber-optic confocal microscope is integrated with the photoacoustic microscope. Thus, simultaneous multimodal imaging can be achieved with a single light source and images from the two modalities are intrinsically registered. Such capabilities are demonstrated in imaging both phantoms and small animals in vivo.

Original languageEnglish (US)
Pages (from-to)1278-1282
Number of pages5
JournalOptics Express
Issue number2
StatePublished - Jan 18 2010

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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