Collecting back-reflected photons in photoacoustic microscopy

Hao F. Zhang, Jing Wang, Qing Wei, Tan Liu, Shuliang Jiao, Carmen A. Puliafito

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Since the photoacoustic effect relies only on the absorbed optical energy, the back-reflected photons from samples in optical-resolution photoacoustic microscopy are usually discarded. By employing a 2 × 2 single-mode fiber optical coupler in a laser-scanning optical-resolution photoacoustic microscope for delivering the illuminating laser light and collecting the back reflected photons, a fiber-optic confocal microscope is integrated with the photoacoustic microscope. Thus, simultaneous multimodal imaging can be achieved with a single light source and images from the two modalities are intrinsically registered. Such capabilities are demonstrated in imaging both phantoms and small animals in vivo.

Original languageEnglish (US)
Pages (from-to)1278-1282
Number of pages5
JournalOptics Express
Volume18
Issue number2
DOIs
StatePublished - Jan 18 2010

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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    Zhang, H. F., Wang, J., Wei, Q., Liu, T., Jiao, S., & Puliafito, C. A. (2010). Collecting back-reflected photons in photoacoustic microscopy. Optics Express, 18(2), 1278-1282. https://doi.org/10.1364/OE.18.001278