Colorimetric screening of DNA-binding molecules with gold nanoparticle probes

Min Su Han*, Abigail K.R. Lytton-Jean, Byung Keun Oh, Jungseok Heo, Chad A. Mirkin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

197 Scopus citations


(Figure Presented) Nanoparticle assemblies interconnected with DNA can be used to screen for DNA-binding molecules colorimetrically. The melting temperature of the nanoparticle assembly increases in the presence of strong-DNA-binding molecules. Thus, the strength of the DNA binding can be determined by the change in this sharp melting transition, which is observable by a blue-to-red color change (see picture).

Original languageEnglish (US)
Pages (from-to)1807-1810
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number11
StatePublished - Mar 3 2006


  • DNA
  • Gold
  • High-throughput screening
  • Nanostructures
  • Sensors

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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