Colposcopic imaging using visible-light optical coherence tomography

Lian Duan; Michael D. McRaven; Wenzhong Liu; Xiao Shu; Jianmin Hu; Cheng Sun; Ronald S. Veazey; Thomas J. Hope; Hao F. Zhang

doi:10.1117/1.JBO.22.5.056003

Colposcopic imaging using visible-light optical coherence tomography

Lian Duan, Michael D. McRaven, Wenzhong Liu, Xiao Shu, Jianmin Hu, Cheng Sun, Ronald S. Veazey, Thomas J. Hope, Hao F. Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

High-resolution colposcopic optical coherence tomography (OCT) provides key anatomical measures, such as thickness and minor traumatic injury of vaginal epithelium, of the female reproductive tract noninvasively. This information can be helpful in both fundamental investigations in animal models and disease screenings in humans. We present a fiber-based visible-light OCT and two probe designs for colposcopic application. One probe conducts circular scanning using a DC motor, and the other probe is capable of three-dimensional imaging over a 4.6 × 4.6-mm² area using a pair of galvo scanners. Using this colposcopic vis-OCT with both probes, we acquired high-resolution images from whole isolated macaque vaginal samples and identified biopsy lesions.

Original language	English (US)
Article number	056003
Journal	Journal of Biomedical Optics
Volume	22
Issue number	5
DOIs	https://doi.org/10.1117/1.JBO.22.5.056003
State	Published - 2017

Funding

We greatly appreciate technical assistance from Dr. Hao Li, Dr. Biqin Dong, and MeaganWatkins.We also acknowledge generous financial support from the National Institutes of Health (NIH) grants R01AI094595, R33AI094584, R24EY022883, and DP3DK108248 and a pilot grant from the Third Coast Center for AIDS Research as part of NIH P30AI117943.

Keywords

Colposcopy
Optical biopsy
Optical coherence tomography
Vaginal imaging

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Biomedical Engineering

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10.1117/1.JBO.22.5.056003

Cite this

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title = "Colposcopic imaging using visible-light optical coherence tomography",

abstract = "High-resolution colposcopic optical coherence tomography (OCT) provides key anatomical measures, such as thickness and minor traumatic injury of vaginal epithelium, of the female reproductive tract noninvasively. This information can be helpful in both fundamental investigations in animal models and disease screenings in humans. We present a fiber-based visible-light OCT and two probe designs for colposcopic application. One probe conducts circular scanning using a DC motor, and the other probe is capable of three-dimensional imaging over a 4.6 × 4.6-mm2 area using a pair of galvo scanners. Using this colposcopic vis-OCT with both probes, we acquired high-resolution images from whole isolated macaque vaginal samples and identified biopsy lesions.",

keywords = "Colposcopy, Optical biopsy, Optical coherence tomography, Vaginal imaging",

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AU - Liu, Wenzhong

AU - Shu, Xiao

AU - Hu, Jianmin

AU - Sun, Cheng

AU - Veazey, Ronald S.

AU - Hope, Thomas J.

AU - Zhang, Hao F.

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AB - High-resolution colposcopic optical coherence tomography (OCT) provides key anatomical measures, such as thickness and minor traumatic injury of vaginal epithelium, of the female reproductive tract noninvasively. This information can be helpful in both fundamental investigations in animal models and disease screenings in humans. We present a fiber-based visible-light OCT and two probe designs for colposcopic application. One probe conducts circular scanning using a DC motor, and the other probe is capable of three-dimensional imaging over a 4.6 × 4.6-mm2 area using a pair of galvo scanners. Using this colposcopic vis-OCT with both probes, we acquired high-resolution images from whole isolated macaque vaginal samples and identified biopsy lesions.

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KW - Optical coherence tomography

KW - Vaginal imaging

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Colposcopic imaging using visible-light optical coherence tomography

Abstract

Funding

Keywords

ASJC Scopus subject areas

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