Colposcopic imaging using visible-light optical coherence tomography

Lian Duan, Michael D. McRaven, Wenzhong Liu, Xiao Shu, Jianmin Hu, Cheng Sun, Ronald S. Veazey, Thomas J. Hope, Hao F. Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


High-resolution colposcopic optical coherence tomography (OCT) provides key anatomical measures, such as thickness and minor traumatic injury of vaginal epithelium, of the female reproductive tract noninvasively. This information can be helpful in both fundamental investigations in animal models and disease screenings in humans. We present a fiber-based visible-light OCT and two probe designs for colposcopic application. One probe conducts circular scanning using a DC motor, and the other probe is capable of three-dimensional imaging over a 4.6 × 4.6-mm2 area using a pair of galvo scanners. Using this colposcopic vis-OCT with both probes, we acquired high-resolution images from whole isolated macaque vaginal samples and identified biopsy lesions.

Original languageEnglish (US)
Article number056003
JournalJournal of Biomedical Optics
Issue number5
StatePublished - 2017


  • Colposcopy
  • Optical biopsy
  • Optical coherence tomography
  • Vaginal imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Biomaterials


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