Combinatorial regulation of tissue specification by GATA and FOG factors

Timothy M. Chlon, John D. Crispino

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations

Abstract

The development of complex organisms requires the formation of diverse cell types from common stem and progenitor cells. GATA family transcriptional regulators and their dedicated cofactors, termed Friend of GATA (FOG) proteins, control cell fate and differentiation in multiple tissue types from Drosophila to man. FOGs can both facilitate and antagonize GATA factor transcriptional regulation depending on the factor, cell, and even the specific gene target. In this review, we highlight recent studies that have elucidated mechanisms by which FOGs regulate GATA factor function and discuss how these factors use these diverse modes of gene regulation to control cell lineage specification throughout metazoans.

Original languageEnglish (US)
Pages (from-to)3905-3916
Number of pages12
JournalDevelopment (Cambridge)
Volume139
Issue number21
DOIs
StatePublished - Nov 1 2012

Keywords

  • Gene regulation
  • Lineage commitment
  • Transcription factors

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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