Combined cancer testis antigens enhanced prediction accuracy for prognosis of patients with hepatocellular carcinoma

Meng Wang, Jiansheng Li, Liping Wang, Xinfeng Chen, Zhen Zhang, Dongli Yue, Yu Ping, Xiaojuan Shi, Lan Huang, Tengfei Zhang, Li Yang, Yongfu Zhao, Xiuxian Ma, Dexu Li, Zhengjun Fan, Longshuan Zhao, Zhe Tang, Wenlong Zhai, Bin Zhang, Yi Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Cancer testis antigens (CTAs) are selectively expressed in malignant cells and can serve as ideal targets for immunotherapy. We investigated the expressions of MAGE-A3, MAGE-A4, MAGE-C2 and NY-ESO-1 to determine if combinatorial expressions of CTAs might be as potential prognostic markers for patients with hepatocellular carcinoma (HCC). In tumor tissues of 142 HCC patients, the mRNA expressions of MAGE-A3, MAGE-A4, MAGE-C2 and NY-ESO-1 were 78.9%, 33.8%, 74.6% and 14.1% respectively. Furthermore, the expressions of MAGE-A3, MAGE-A4 and combination of MAGE-A3, MAGE-A4 and NY-ESO-1 (CTAs-A3/A4/NY) showed positive correlations with serum AFP, tumor stages and Ki-67 (P < 0.05). In addition, mRNA expressions of CTAs were significantly consistent with protein expressions of CTAs by immunohistochemistry (P > 0.05). Receiver operating characteristic curves (ROC) analysis showed that CTAs-A3/A4/NY had larger areas under ROC curve (0.768), specificity (99.1%), Youden's index (44.6), positive predictive value (90.9%) and negative predictive value (89.9%) for predicting HCC recurrence than other CTAs. Moreover, the combinatorial expression of CTAs-A3/A4/NY was significantly associated with HCC recurrence by Kaplan-Meier analysis (HR = 69.36, P < 0.01) and multivariate Cox analysis (RR = 17.11, P < 0.01). The combinatorial expression of CTAs-A3/A4/NY mRNA promotes the predictive accuracy of HCC recurrence and itself may be a potential target for immunotherapy of HCC as well.

Original languageEnglish (US)
Pages (from-to)3513-3528
Number of pages16
JournalInternational Journal of Clinical and Experimental Pathology
Volume8
Issue number4
StatePublished - Jan 1 2015

Keywords

  • Cancer testis antigen
  • Hepatocellular carcinoma
  • Marker
  • Prognosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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