Combined cutaneous tumors with a melanoma component: A clinical, histologic, and molecular study

Sapna M. Amin, Chelsea Cooper, Oriol Yélamos, Christina Y. Lee, Lauren M. Sholl, Arnaud De La Fouchardiere, Joan Guitart, Pedram Gerami*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Background The histogenesis and clinical behavior of combined cutaneous tumors (CCTs) in which the mesenchymal component consists of melanoma remain unclear. Objective We sought to characterize the clinical, histologic, and molecular findings in CCTs with an epithelial and a melanoma component. Methods We retrospectively reviewed the records from 2 institutions for CCTs. Fluorescence in situ hybridization was performed to assess chromosomal copy number alterations in both components. Results Sixteen CCTs were included. The most common subtype was the squamomelanocytic tumor (11), followed by the basomelanocytic tumor (3) and the trichoblastomelanoma (2). CCTs were more common in men (87%), on the head and neck (57%), and had extensive solar elastosis (81%). The median follow-up was 25 months (range, 8-167 months). One case had an adverse outcome. Fluorescence in situ hybridization revealed chromosomal alterations in approximately 55% of the cases. Five cases showed chromosomal gains only in the melanocytic component. One case showed 11q13 gains in both the epithelial and melanocytic components. Limitations Our study is retrospective and the sample is small. Conclusions The low incidence of adverse outcomes suggests that CCT may be more indolent than noncombined tumors. 11q13 amplification in both components supports the theory of dual differentiation from a common progenitor cell.

Original languageEnglish (US)
Pages (from-to)451-460
Number of pages10
JournalJournal of the American Academy of Dermatology
Issue number3
StatePublished - Sep 1 2015


  • basomelanocytic tumor
  • biphenotypia
  • combined tumor
  • fluorescence in situ hybridization
  • melanoma
  • squamomelanocytic tumor
  • trichoblastomelanoma

ASJC Scopus subject areas

  • Dermatology


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