TY - JOUR
T1 - Combined modality approaches in the management of adult glioblastoma
AU - Shirazi, Haider A.
AU - Grimm, Sean
AU - Raizer, Jeffrey
AU - Mehta, Minesh P.
PY - 2011
Y1 - 2011
N2 - Over the past two decades, management of newly diagnosed glioblastoma has undergone significant evolution. While surgery has long been a mainstay of management for this disease, and while radiotherapy has a proven survival role, initial efforts at radiotherapy dose escalation, use of radiosurgery, brachytherapy, and altered fractionation did not improve patient survival. Recently, multiple modality therapy integrating maximal safe resection, postoperative radiation, and new systemic therapies have resulted in improved patient outcomes compared with older regimens utilizing surgery and postoperative radiation alone. Numerous trials are currently underway investigating the combination of surgery, radiation, and systemic therapy with targeted agents to find ways to further improve outcomes for adults with glioblastoma.
AB - Over the past two decades, management of newly diagnosed glioblastoma has undergone significant evolution. While surgery has long been a mainstay of management for this disease, and while radiotherapy has a proven survival role, initial efforts at radiotherapy dose escalation, use of radiosurgery, brachytherapy, and altered fractionation did not improve patient survival. Recently, multiple modality therapy integrating maximal safe resection, postoperative radiation, and new systemic therapies have resulted in improved patient outcomes compared with older regimens utilizing surgery and postoperative radiation alone. Numerous trials are currently underway investigating the combination of surgery, radiation, and systemic therapy with targeted agents to find ways to further improve outcomes for adults with glioblastoma.
KW - Chemotherapy
KW - Glioblastoma
KW - Radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=84891619832&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891619832&partnerID=8YFLogxK
U2 - 10.3389/fonc.2011.00036
DO - 10.3389/fonc.2011.00036
M3 - Review article
C2 - 22655242
AN - SCOPUS:84891619832
VL - 1
JO - Frontiers in Oncology
JF - Frontiers in Oncology
SN - 2234-943X
IS - OCT
M1 - 00036
ER -