Combined plasmapheresis and high-dose intravenous immunoglobulin treatment in systemic sclerosis for 12 months: Follow-up of immunopathological and clinical effects

Zoltán Szekanecz; Magdolna Aleksza; Péter Antal-Szalmás; Pál Soltész; Katalin Veres; Sándor Szántó; Zoltán Szabó; Anikó Végvári; Szilvia Szamosi; Gabriella Lakos; Sándor Sipka; Gyula Szegedi; John Varga; Gabriella Szücs

doi:10.1007/s10067-008-1062-2

Combined plasmapheresis and high-dose intravenous immunoglobulin treatment in systemic sclerosis for 12 months: Follow-up of immunopathological and clinical effects

Zoltán Szekanecz^*, Magdolna Aleksza, Péter Antal-Szalmás, Pál Soltész, Katalin Veres, Sándor Szántó, Zoltán Szabó, Anikó Végvári, Szilvia Szamosi, Gabriella Lakos, Sándor Sipka, Gyula Szegedi, John Varga, Gabriella Szücs

^*Corresponding author for this work

Medicine, Rheumatology Division

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Systemic sclerosis (SSc) is an autoimmune disease which involves the skin, as well as several internal organs. Most therapies available in this disease are symptomatic. Authors present a case of diffuse SSc with progressive disease not responding to currently available treatments. Therefore a 12-month protocol of repeated plasmapheresis and high-dose intravenous immunoglobulin treatment was administered with good clinical efficacy. Apart from monitoring the clinical symptoms throughout the treatment, authors also assessed a number of humoral and cellular immunolaboratory markers in order to obtain information on the immunomodulatory effects of this combined treatment in SSc.

Original language	English (US)
Pages (from-to)	347-350
Number of pages	4
Journal	Clinical Rheumatology
Volume	28
Issue number	3
DOIs	https://doi.org/10.1007/s10067-008-1062-2
State	Published - 2009

Keywords

Intravenous immunoglobulin
Plasmapheresis
Systemic sclerosis

ASJC Scopus subject areas

Rheumatology

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10.1007/s10067-008-1062-2

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Szekanecz, Z., Aleksza, M., Antal-Szalmás, P., Soltész, P., Veres, K., Szántó, S., Szabó, Z., Végvári, A., Szamosi, S., Lakos, G., Sipka, S., Szegedi, G., Varga, J., & Szücs, G. (2009). Combined plasmapheresis and high-dose intravenous immunoglobulin treatment in systemic sclerosis for 12 months: Follow-up of immunopathological and clinical effects. Clinical Rheumatology, 28(3), 347-350. https://doi.org/10.1007/s10067-008-1062-2

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abstract = "Systemic sclerosis (SSc) is an autoimmune disease which involves the skin, as well as several internal organs. Most therapies available in this disease are symptomatic. Authors present a case of diffuse SSc with progressive disease not responding to currently available treatments. Therefore a 12-month protocol of repeated plasmapheresis and high-dose intravenous immunoglobulin treatment was administered with good clinical efficacy. Apart from monitoring the clinical symptoms throughout the treatment, authors also assessed a number of humoral and cellular immunolaboratory markers in order to obtain information on the immunomodulatory effects of this combined treatment in SSc.",

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author = "Zolt{\'a}n Szekanecz and Magdolna Aleksza and P{\'e}ter Antal-Szalm{\'a}s and P{\'a}l Solt{\'e}sz and Katalin Veres and S{\'a}ndor Sz{\'a}nt{\'o} and Zolt{\'a}n Szab{\'o} and Anik{\'o} V{\'e}gv{\'a}ri and Szilvia Szamosi and Gabriella Lakos and S{\'a}ndor Sipka and Gyula Szegedi and John Varga and Gabriella Sz{\"u}cs",

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doi = "10.1007/s10067-008-1062-2",

language = "English (US)",

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Szekanecz, Z, Aleksza, M, Antal-Szalmás, P, Soltész, P, Veres, K, Szántó, S, Szabó, Z, Végvári, A, Szamosi, S, Lakos, G, Sipka, S, Szegedi, G, Varga, J & Szücs, G 2009, 'Combined plasmapheresis and high-dose intravenous immunoglobulin treatment in systemic sclerosis for 12 months: Follow-up of immunopathological and clinical effects', Clinical Rheumatology, vol. 28, no. 3, pp. 347-350. https://doi.org/10.1007/s10067-008-1062-2

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T2 - Follow-up of immunopathological and clinical effects

AU - Szekanecz, Zoltán

AU - Aleksza, Magdolna

AU - Antal-Szalmás, Péter

AU - Soltész, Pál

AU - Veres, Katalin

AU - Szántó, Sándor

AU - Szabó, Zoltán

AU - Végvári, Anikó

AU - Szamosi, Szilvia

AU - Lakos, Gabriella

AU - Sipka, Sándor

AU - Szegedi, Gyula

AU - Varga, John

AU - Szücs, Gabriella

PY - 2009

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AB - Systemic sclerosis (SSc) is an autoimmune disease which involves the skin, as well as several internal organs. Most therapies available in this disease are symptomatic. Authors present a case of diffuse SSc with progressive disease not responding to currently available treatments. Therefore a 12-month protocol of repeated plasmapheresis and high-dose intravenous immunoglobulin treatment was administered with good clinical efficacy. Apart from monitoring the clinical symptoms throughout the treatment, authors also assessed a number of humoral and cellular immunolaboratory markers in order to obtain information on the immunomodulatory effects of this combined treatment in SSc.

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KW - Plasmapheresis

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Combined plasmapheresis and high-dose intravenous immunoglobulin treatment in systemic sclerosis for 12 months: Follow-up of immunopathological and clinical effects

Abstract

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ASJC Scopus subject areas

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