Combined thrombolytic therapy for prosthetic mitral valve thrombosis

Charles M T Jost, Clyde W. Yancy*, W. Steves Ring

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Prosthetic valve thrombosis is associated with high mortality. The treatment of choice remains operation. This is a case report of the successful combination therapy of tissue plasminogen activator and urokinase for an isolated thrombosed prosthetic mitral valve in a postpartum patient in whom operation was thought to carry an unacceptable risk. Combined thrombolytic therapy or therapy with a single agent with a long half-life and a prolonged infusion time is suggested as an emergent treatment option for prosthetic mitral valve thrombosis.

Original languageEnglish (US)
Pages (from-to)159-161
Number of pages3
JournalThe Annals of thoracic surgery
Issue number1
StatePublished - Jan 1993

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery


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