Combining high dose therapy, bilateral motor priming, and vagus nerve stimulation to treat the hemiparetic upper limb in chronic stroke survivors: a perspective on enhancing recovery

Erin C. King*, Elizabeth Pedi, Mary Ellen Stoykov, Daniel M. Corcos, Sebastian Urday

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Stroke is a leading cause of disability worldwide and upper limb hemiparesis is the most common post-stroke disability. Recent studies suggest that clinically significant motor recovery is possible in chronic stroke survivors with severe impairment of the upper limb. Three promising strategies that have been investigated are (1) high dose rehabilitation therapy (2) bilateral motor priming and (3) vagus nerve stimulation. We propose that the future of effective and efficient upper limb rehabilitation will likely require a combination of these approaches.

Original languageEnglish (US)
Article number1182561
JournalFrontiers in Neurology
Volume14
DOIs
StatePublished - 2023

Funding

This research is supported by National Institutes of Health (1RO1HD091492). EK is supported by 1F31HD111318-01. EP is supported by T32HD101395. The authors would like to thank the National Institutes of Health, Northwestern University, Shirley Ryan AbilityLab, and Northwestern Medicine for their support, grants, and funding of ongoing clinical trials for advancement of clinical practice and education.

Keywords

  • priming
  • rehabilitation
  • stroke
  • task specific training
  • vagus nerve stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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