Combining high dose therapy, bilateral motor priming, and vagus nerve stimulation to treat the hemiparetic upper limb in chronic stroke survivors: a perspective on enhancing recovery

Erin C. King; Elizabeth Pedi; Mary Ellen Stoykov; Daniel M. Corcos; Sebastian Urday

doi:10.3389/fneur.2023.1182561

Combining high dose therapy, bilateral motor priming, and vagus nerve stimulation to treat the hemiparetic upper limb in chronic stroke survivors: a perspective on enhancing recovery

Erin C. King^*, Elizabeth Pedi, Mary Ellen Stoykov, Daniel M. Corcos, Sebastian Urday

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Stroke is a leading cause of disability worldwide and upper limb hemiparesis is the most common post-stroke disability. Recent studies suggest that clinically significant motor recovery is possible in chronic stroke survivors with severe impairment of the upper limb. Three promising strategies that have been investigated are (1) high dose rehabilitation therapy (2) bilateral motor priming and (3) vagus nerve stimulation. We propose that the future of effective and efficient upper limb rehabilitation will likely require a combination of these approaches.

Original language	English (US)
Article number	1182561
Journal	Frontiers in Neurology
Volume	14
DOIs	https://doi.org/10.3389/fneur.2023.1182561
State	Published - 2023

Funding

This research is supported by National Institutes of Health (1RO1HD091492). EK is supported by 1F31HD111318-01. EP is supported by T32HD101395. The authors would like to thank the National Institutes of Health, Northwestern University, Shirley Ryan AbilityLab, and Northwestern Medicine for their support, grants, and funding of ongoing clinical trials for advancement of clinical practice and education.

Keywords

priming
rehabilitation
stroke
task specific training
vagus nerve stimulation

ASJC Scopus subject areas

Clinical Neurology
Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fneur.2023.1182561

Cite this

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title = "Combining high dose therapy, bilateral motor priming, and vagus nerve stimulation to treat the hemiparetic upper limb in chronic stroke survivors: a perspective on enhancing recovery",

abstract = "Stroke is a leading cause of disability worldwide and upper limb hemiparesis is the most common post-stroke disability. Recent studies suggest that clinically significant motor recovery is possible in chronic stroke survivors with severe impairment of the upper limb. Three promising strategies that have been investigated are (1) high dose rehabilitation therapy (2) bilateral motor priming and (3) vagus nerve stimulation. We propose that the future of effective and efficient upper limb rehabilitation will likely require a combination of these approaches.",

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author = "King, {Erin C.} and Elizabeth Pedi and Stoykov, {Mary Ellen} and Corcos, {Daniel M.} and Sebastian Urday",

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AU - Pedi, Elizabeth

AU - Stoykov, Mary Ellen

AU - Corcos, Daniel M.

AU - Urday, Sebastian

N1 - Funding Information: This research is supported by National Institutes of Health (1RO1HD091492). EK is supported by 1F31HD111318-01. EP is supported by T32HD101395. Funding Information: The authors would like to thank the National Institutes of Health, Northwestern University, Shirley Ryan AbilityLab, and Northwestern Medicine for their support, grants, and funding of ongoing clinical trials for advancement of clinical practice and education. Publisher Copyright: Copyright © 2023 King, Pedi, Stoykov, Corcos and Urday.

PY - 2023

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AB - Stroke is a leading cause of disability worldwide and upper limb hemiparesis is the most common post-stroke disability. Recent studies suggest that clinically significant motor recovery is possible in chronic stroke survivors with severe impairment of the upper limb. Three promising strategies that have been investigated are (1) high dose rehabilitation therapy (2) bilateral motor priming and (3) vagus nerve stimulation. We propose that the future of effective and efficient upper limb rehabilitation will likely require a combination of these approaches.

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Combining high dose therapy, bilateral motor priming, and vagus nerve stimulation to treat the hemiparetic upper limb in chronic stroke survivors: a perspective on enhancing recovery

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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