Comment on “Circadian rhythms in the absence of the clock gene Bmal1 ”

Elan Ness-Cohn, Ravi Allada, Rosemary Braun*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

11 Scopus citations


Ray et al (Reports, 14 February 2020, p. 800) report apparent transcriptional circadian rhythms in mouse tissues lacking the core clock component BMAL1. To better understand these surprising results, we reanalyzed the associated data. We were unable to reproduce the original findings, nor could we identify reliably cycling genes. We conclude that there is insufficient evidence to support circadian transcriptional rhythms in the absence of Bmal1.

Original languageEnglish (US)
Article numbereabe9230
Issue number6539
StatePublished - Apr 16 2021

ASJC Scopus subject areas

  • General


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