Comment on “Circadian rhythms in the absence of the clock gene Bmal1 ”

Elan Ness-Cohn, Ravi Allada, Rosemary Braun

Research output: Contribution to journalComment/debatepeer-review

1 Scopus citations

Abstract

Ray et al (Reports, 14 February 2020, p. 800) report apparent transcriptional circadian rhythms in mouse tissues lacking the core clock component BMAL1. To better understand these surprising results, we reanalyzed the associated data. We were unable to reproduce the original findings, nor could we identify reliably cycling genes. We conclude that there is insufficient evidence to support circadian transcriptional rhythms in the absence of Bmal1.

Original languageEnglish (US)
Article numbereabe9230
JournalScience
Volume372
Issue number6539
DOIs
StatePublished - Apr 16 2021

ASJC Scopus subject areas

  • General

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