Comment on "Progesterone/RANKL is a major regulatory axis in the human breast"

Jun Wang, Akash Gupta, Hong Hu, Robert T. Chatterton, Charles V. Clevenger, Seema A. Khan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


In vivo menstrual cycle data support the findings by Tanos et al. that progesterone regulates RANKL in an ex vivo microstructure model of the human breast, but dispute the suppression of estradiol on progesterone-stimulated RANKL expression. RANKL responds to progesterone in a three-dimensional organoid culture model under conditions mimicking luteal-phase hormone concentration, suggesting that the microstructure may not be crucial to demonstrate progesterone responsiveness.

Original languageEnglish (US)
Article number215le4
JournalScience translational medicine
Issue number215
StatePublished - Dec 11 2013

ASJC Scopus subject areas

  • Medicine(all)


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