TY - JOUR
T1 - Comment on "Progesterone/RANKL is a major regulatory axis in the human breast"
AU - Wang, Jun
AU - Gupta, Akash
AU - Hu, Hong
AU - Chatterton, Robert T.
AU - Clevenger, Charles V.
AU - Khan, Seema A.
PY - 2013/12/11
Y1 - 2013/12/11
N2 - In vivo menstrual cycle data support the findings by Tanos et al. that progesterone regulates RANKL in an ex vivo microstructure model of the human breast, but dispute the suppression of estradiol on progesterone-stimulated RANKL expression. RANKL responds to progesterone in a three-dimensional organoid culture model under conditions mimicking luteal-phase hormone concentration, suggesting that the microstructure may not be crucial to demonstrate progesterone responsiveness.
AB - In vivo menstrual cycle data support the findings by Tanos et al. that progesterone regulates RANKL in an ex vivo microstructure model of the human breast, but dispute the suppression of estradiol on progesterone-stimulated RANKL expression. RANKL responds to progesterone in a three-dimensional organoid culture model under conditions mimicking luteal-phase hormone concentration, suggesting that the microstructure may not be crucial to demonstrate progesterone responsiveness.
UR - http://www.scopus.com/inward/record.url?scp=84891699431&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891699431&partnerID=8YFLogxK
U2 - 10.1126/scitranslmed.3006883
DO - 10.1126/scitranslmed.3006883
M3 - Article
C2 - 24337478
AN - SCOPUS:84891699431
SN - 1946-6234
VL - 5
JO - Science translational medicine
JF - Science translational medicine
IS - 215
M1 - 215le4
ER -