Commentary: Defining treatment refractoriness in schizophrenia

H. Y. Meltzer*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

50 Scopus citations


The criteria for treatment refractoriness for the use of clozapine are necessarily set at a high level because of the potential risk of agranulocytosis with this treatment. However, a more liberal definition should be considered to better appreciate the limitations of current therapies and prepare for switching to the next generation of clozapine-like drugs that do not cause agranulocytosis. It is suggested that failure of therapy to bring about the best premorbid level of functioning be considered as a starting point for treatment-resistance.

Original languageEnglish (US)
Pages (from-to)563-565
Number of pages3
JournalSchizophrenia bulletin
Issue number4
StatePublished - 1990

ASJC Scopus subject areas

  • Psychiatry and Mental health


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